Abstract
The polyvinyl alcohol (PVA) hydrogel containing 1-methyl-2-pyrrolidinone (MP) and sorbitol was preapred by the freeze and thaw method. The release rate of indomethacin from PVA hydrogel was used as a criterion for deciding the optimum formula of hydrogel using the computer optimization technique. The hydrogel of optimum formula was composed of PVA (10 w/v%), MP (0 w/v%), and sorbitol (40 w/v%) and the release rate of indomethacin was 1.981 μg/ml·min1/2.
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Lee, C.H., Lee, K.J., Park, A.J. et al. Studies on controlled release of indomethacin from PVA hydrogel. Arch. Pharm. Res. 16, 43–49 (1993). https://doi.org/10.1007/BF02974127
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DOI: https://doi.org/10.1007/BF02974127