Abstract
The activity-oriented fractionation ofPsoralea corylifolia led to an isolation of a (+)-bakuchiol1 as an active principle of its antitumoral propertyin vitro.1 was observed to exhibit a mild cytotoxicity against five kinds of cultured human cancer cell lines,i.e. the A549, SK-OV-3, SK-MEL-2, XF498 and HCT15. The synthesized 2,3-epoxide of (+)-bakuchiol3 showed the similar activity as the (+)-bakuchiol1, whereas the other oxidation derivatives4 and5 including the acetyl-(+)-bakuchiol2 showed a decreased activity.
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Ryu, S.Y., Choi, S.U., Lee, C.O. et al. Antitumor activity ofPsoralea corylifolia . Arch. Pharm. Res. 15, 356–359 (1992). https://doi.org/10.1007/BF02974112
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DOI: https://doi.org/10.1007/BF02974112