Synthesis of 7-hydroxy-4-Oxo-4H-chromene- and 7-hydroxychroman-2-carboxylic acidN-alkyl amides and their antioxidant activities

An Erratum to this article was published on 01 October 2006

Abstract

A series of 7-hydroxy-4-oxo-4H-chromene- (3a-h) and 7-hydroxychroman-2-carboxylic acidN-alkyl amides (4a-g) were synthesized and their antioxidant activities were evaluated. While compounds3a-h were less active, compounds4a-g exhibited more potent inhibition of lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. Among them, 7-hydroxychroman-2-carboxylic acidN-alkylamides (4e-g) bearing nonyl, decyl, and undecyl side chain exhibited 3 times more potent inhibition than trolox (1).

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Correspondence to Heesoon Lee.

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An erratum to this article is available at http://dx.doi.org/10.1007/BF02973917.

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Kwak, JH., Kang, HE., Jung, JK. et al. Synthesis of 7-hydroxy-4-Oxo-4H-chromene- and 7-hydroxychroman-2-carboxylic acidN-alkyl amides and their antioxidant activities. Arch Pharm Res 29, 728–734 (2006). https://doi.org/10.1007/BF02974071

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Key words

  • Antioxidant activity
  • 7-Hydroxychroman-2-carboxylic acidN-alkyl amides