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Synthesis of antineoplaston A10 analogs as potential antitumor agents

Abstract

Several aniline mustard analogues were obtained by introducingN,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. Thein vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially,m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.

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Choi, BG., Kim, OY., Chung, BH. et al. Synthesis of antineoplaston A10 analogs as potential antitumor agents. Arch. Pharm. Res. 21, 157–163 (1998). https://doi.org/10.1007/BF02974021

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  • DOI: https://doi.org/10.1007/BF02974021

Key words

  • Antineoplaston A10
  • Aniline mustards
  • Piperidinedione derivatives
  • Antitumor agent