Abstract
2,3-Diphenyl-6-formyl-5-methoxyindole reacts with ethyl cyano acetate to yield the arylidene derivative which forms with urea and thiourea the corresponding pyrimidine derivatives. The arylidene derivatives react with hydrazines and with active methylenes to form the respective pyrazole derivatives and the α, β-disubstituted acrylonitriles. Seven new compounds were tested for their effects on the arterial blood pressure of rats and analgesic activity.
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Hishmat, O.H., Nakkady, S.S., El Shabrawy, O.A. et al. Synthesis and biological activities of new substituted indoles. Arch. Pharm. Res. 15, 104–108 (1992). https://doi.org/10.1007/BF02973994
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DOI: https://doi.org/10.1007/BF02973994