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Synthesis of some new 4-substituted antipyrines as potential antipyretic analgesics

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Abstract

4-Acetylantipyrine1 underwent condensation with 4-formyl-antipyrine2 to give3. Condensation of either3 with1 or1 with2 in a molar ratio of (2∶1) afforded4. Cyclization of4 in the presence of PPA and ammonium acetate or 4-aminoantipyrine in the presence of glacial acetic acid gave5–7, respectively. Claisen condensation of1 with ethyl acetate and diethyl oxalate afforded compounds8–10. The reaction of1 and2 with indole in ethanol/conc. hydrochloric acid was also investigated.

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  1. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

    M. Hammouda

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  1. M. Hammouda
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Hammouda, M. Synthesis of some new 4-substituted antipyrines as potential antipyretic analgesics. Arch. Pharm. Res. 15, 1–4 (1992). https://doi.org/10.1007/BF02973975

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