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Determination of isoprenyl and lavandulyl positions of flavonoids fromSophora flavescens by NMR experiment

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Abstract

All fifteen flavonoids (1∼15) have been isolated from the roots ofSophora flavescens (Leguminosae) as active principles of the cytotoxic property toward human tumor cell lines such as A549, SK-OV-3, SK-Mel-2, XF498 and HCT15,in vitro. By means of spectral analyses, particularly by the aid of various two dimensional NMR experiments, all1H-NMR and13C-NMR signals of1∼15 were completely assigned, and thus the structures of1∼15 were established unambiguously.

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Authors and Affiliations

  1. Korea Research Institute of Chemical Technology, Yusung, P.O. Box 107, 305-606, Taejeon, Korea

    Shi Yong Ryu

  2. Korea Research Institute of Bioscience and Biotechnology, KRIBB, Yusung, P.O. Box 115, 305-600, Taejeon, Korea

    Hyun Sun Lee

  3. Department of Forest Products, Kookmin University, 136-702, Seoul, Korea

    Young Kyoon Kim

  4. Oriental Medical College, Taejeon University, 300-716, Taejeon, Korea

    Sung Hoon Kim

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  1. Shi Yong Ryu
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  2. Hyun Sun Lee
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  3. Young Kyoon Kim
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  4. Sung Hoon Kim
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Ryu, S.Y., Lee, H.S., Kim, Y.K. et al. Determination of isoprenyl and lavandulyl positions of flavonoids fromSophora flavescens by NMR experiment. Arch. Pharm. Res. 20, 491–495 (1997). https://doi.org/10.1007/BF02973946

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  • DOI: https://doi.org/10.1007/BF02973946

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