Journal of Biosciences

, Volume 28, Issue 3, pp 349–358 | Cite as

Host-pathogen interactions during apoptosis

  • Seyed E. HasnainEmail author
  • Rasheeda Begum
  • K. V. A. Ramaiah
  • Sudhir Sahdev
  • E. M. Shajil
  • Tarvinder K. Taneja
  • Manjari Mohan
  • M. Athar
  • Nand K. Sah
  • M. Krishnaveni


Host pathogen interaction results in a variety of responses, which include phagocytosis of the pathogen, release of cytokines, secretion of toxins, as well as production of reactive oxygen species (ROS). Recent studies have shown that many pathogens exert control on the processes that regulate apoptosis in the host. The induction of apoptosis upon infection results from a complex interaction of parasite proteins with cellular host proteins. Abrogation of host cell apoptosis is often beneficial for the pathogen and results in a successful host invasion. However, in some cases, it has been shown that induction of apoptosis in the infected cells significantly imparts protection to the host from the pathogen. There is a strong correlation between apoptosis and the host protein translation machinery: the pathogen makes all possible efforts to modify this process so as to inhibit cell suicide and ensure that it can survive and, in some cases, establish latent infection. This review discusses the significance of various pathways/steps during virus-mediated modulation of host cell apoptosis.


Antioxidant baculovirus host-pathogen eIF2α-kinase P35 PKR 

Abbreviations used


Autographa californica nuclear polyhydrosis virus


encephalomyocarditis virus


Fas-associated death domain protein




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Copyright information

© Indian Academy of Sciences 2003

Authors and Affiliations

  • Seyed E. Hasnain
    • 1
    • 2
    • 3
    Email author
  • Rasheeda Begum
    • 4
  • K. V. A. Ramaiah
    • 5
  • Sudhir Sahdev
    • 1
  • E. M. Shajil
    • 4
  • Tarvinder K. Taneja
    • 2
  • Manjari Mohan
    • 2
  • M. Athar
    • 6
  • Nand K. Sah
    • 2
  • M. Krishnaveni
    • 1
  1. 1.Laboratory of Molecular and Cellular BiologyCentre for DNA Fingerprinting and DiagnosticsHyderabadIndia
  2. 2.Eukaryotic Gene Expression LabNational Institute of ImmunologyNew DelhiIndia
  3. 3.Jawaharlal Nehru Centre for Advanced Scientific ResearchBangaloreIndia
  4. 4.Department of BiochemistryM S University of BarodaVadodaraIndia
  5. 5.Department of BiochemistryUniversity of HyderabadHyderabadIndia
  6. 6.Department of Medical Elementology and ToxicologyJamia HamdardNew DelhiIndia

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