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Polymorphism of doxazosin mesylate

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Abstract

Nine polymorphic modifications of doxazosin mesylate have been obtained by recrystallization in organic solvents under variable conditions. Different polymorphs of doxazosin mesylate were characterized by powder X-ray crystallography diffractometry (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). Transformation of Form 1 and Form 2 was not occurred in three relative humidities (0%, 51%, and 99%) at 20±0.5 for 30 days.

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Authors and Affiliations

  1. College of Pharmacy, Duksung Women's University, 419 Ssangmun-Dong, Dobong-Gu, 132-714, Seoul, Korea

    Young-Taek Sohn & Yoon-Hee Lee

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  1. Young-Taek Sohn
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  2. Yoon-Hee Lee
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Correspondence to Young-Taek Sohn.

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Sohn, YT., Lee, YH. Polymorphism of doxazosin mesylate. Arch Pharm Res 28, 730–735 (2005). https://doi.org/10.1007/BF02969365

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