Polymorphism of doxazosin mesylate
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Nine polymorphic modifications of doxazosin mesylate have been obtained by recrystallization in organic solvents under variable conditions. Different polymorphs of doxazosin mesylate were characterized by powder X-ray crystallography diffractometry (PXRD), differential scanning calorimetry (DSC), and thermogravimetric analysis (TG). Transformation of Form 1 and Form 2 was not occurred in three relative humidities (0%, 51%, and 99%) at 20±0.5 for 30 days.
Key wordsDoxazosin mesylate Polymorphism PXRD DSC TG Transformation
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- Gridhar, T., Reddy, R. B., and Ramesh, C., Methods for the preparation of polymorphs of doxazosin mesylate.US 6, 399, 775B1 (2002).Google Scholar
- Kuhnert-Brandstaetter, M., Polymorphie von Arzneitoffen und ihre Bedeutung in der pharmazeutischen Technologie.Informationsdienst A.P.V., 19, 73–90 (1973).Google Scholar
- Sohn, Y. T., Effect of polymorphism on bioavailability of amoxicillin.Yakhak Hoeji, 39, 438–443 (1995).Google Scholar