Skip to main content
SpringerLink
Log in

Effect of flavors on the viscosity and gelling point of aqueous poloxamer solution

  • Articles
  • Drug Efficacy
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

This study examined the effects of flavors, which are usually added to improve the appeal of pharmaceutical agents, on the viscosity and gelling point of 18% (w/w) aqueous poloxamer 407 solutions. Monoterpenes, esters, alcohols, aldehyde ketones and lactone type flavors were examined. The concentrations of flavor ranged from 0.1 to 1.0%(w/w). After adding a flavor to the aqueous poloxamer 407 solution, the viscosity of the solution was measured using a Brookfield viscometer, and the gelling point was determined from the viscosity vs. temperature plot. The gelling point of the aqueous poloxamer 407 solution decreased with increasing concentration of flavors except for coumarin, vanillin and ethylvanillin. Thermal analysis with DSC showed an interaction between the flavors and poloxamer 407. These results suggest that the flavors bind to the hydrophilic end chains of poloxamer 407, which increases the viscosity. causing gelation at lower temperatures.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Abdel-Hamid, S. M., Abdel-Hady, S. E., El-Shamy, A. A., and El-Dessouky, H. F., Formulation of an antispasmodic drug as a topical local anesthetic.Int. J. Pharm., 326, 107–118 (2006).

    Article  PubMed  CAS  Google Scholar 

  • Alexandridis, P. and Hatton, T. A., Poly(ethylene oxide)-poly (propylene oxide)-poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling.Colloids and Surfaces, 96, 1–46 (1995).

    Article  CAS  Google Scholar 

  • Attwood, D., Collett, J. H., and Tait, C. J., The micellar properties of the poly (oxyethylene)-poly(oxypropylene) copolymer Pluronic F 127 in water and electrolyte solution.Int. J. Pharm., 26, 25–33 (1985).

    Article  CAS  Google Scholar 

  • Bahadur, P., Pandya, K., Almgren, M., Li, P., and Stilbs, P., Effect of inorganic salts on the micellar behaviour of ethylene oxide-propylene oxide block copolymers in aqueous solution.Colloid. Polym. Sci., 271, 651–667 (1993).

    Article  Google Scholar 

  • Bohorquez, M., Koch, C., Trygstad, T., and Pandit, N., A study of the temperature-dependent micellization of pluronic F127.J. Colloid Interface Sci., 216, 34–40 (1999).

    Article  PubMed  CAS  Google Scholar 

  • Brown, W., Schillen, K., Almgren, M., Hvidt, S., and Bahadur, P., Micelle and gel formation in a poly(ethylene oxide)/poly (propylene oxide)/poly(ethylene oxide) triblock copolymer in water solution. Dynamic and static light scattering and oscillatory shear measurements.J. Phys. Chem., 95, 1850–1858 (1991).

    Article  CAS  Google Scholar 

  • Cabana, A., Ait-kadi, A., and Juhasz, J., Study of the gelation process of polyethylene oxidea-polypropylene oxidebpolyethylene oxidea copolymer (poloxamer 407) aqueous solution.J. Colloid Interface Sci., 190, 307–312 (1997).

    Article  PubMed  CAS  Google Scholar 

  • Collett, J. H. and Tobin, E. A., Relationships between poloxamer structure and the solubilization of some para-substituted acetanilides.J. Pharm. Pharmacol., 31, 174–177 (1979).

    PubMed  CAS  Google Scholar 

  • Fawaz, F., Koffia, A., Guyot, M., and Millet, P., Comparative in vitro-in vivo study of two quinine rectal gel formulations.Int. J. Pharm., 280, 151–162 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Gilbert, J. C., Hadgraft, J., Bye, A., and Brookes, L. G., Drug release from Pluronic F-127 gels.Int. J. Pharm., 32, 223–228 (1986).

    Article  CAS  Google Scholar 

  • Gilbert, J. C., Richardson, J. L., Davies, M. C., Palin, K. J., and Hadgraft, J., The effect of solutes and polymers on the gelation properties of Pluronic P-127 solutions for controlled drug delivery.J. Control. Rel., 5, 113–118 (1987).

    Article  CAS  Google Scholar 

  • Guzman, M., Aberturas, M. R., Garcia, F., and Molpeceres, J., Gelatin gels and polyoxyethylene-polyoxypropylene gels: comparative study of their properties.Drug Dev. Ind. Pharm., 20, 2041–2048 (1994).

    Article  CAS  Google Scholar 

  • Hecht, E., Mortensen, K., Gradzielski, M., and Hoffmann, H., Interaction of ABA block copolymers with ionic surfactants: Influence on micellization and gelation.J. Phys. Chem., 99, 4866–4874 (1995).

    Article  CAS  Google Scholar 

  • Johnston, T. P. and Miller, S. C., Inulin disposition following intramuscular administration of an inulin/poloxamer gel matrix.J. Parent. Sci. Technol., 43, 279–286 (1989).

    CAS  Google Scholar 

  • Khidr, S.H., Effect of block copolymers on the dissolution of some water-insoluble drugs: 1. Nifedipine-Pluronic F-127 solid dispersion system.Bull. Pharm. Sci., 17, 81–86 (1994).

    CAS  Google Scholar 

  • Kim, E. Y., Gao, Z. G., Park, J. S., Li, H., and Han, K., rhEGF/HP-β-CD complex in poloxamer gel for ophthalmic delivery.Int. J. Pharm., 233, 159–167 (2002).

    Article  PubMed  CAS  Google Scholar 

  • Martin, A.,Physical Pharmacy, 4th, Lea & Febiger, Philadelphia, U.S.A., pp. 453–476 (1993).

    Google Scholar 

  • Mastroianni, M. J., Pikal, M. J., and Lindenbaum, S., Effect of dimethyl sulfoxide, urea, guanidine hydrochloride and sodium chloride on hydrophobic interactions. Heats of dilution of tetrabutylammonium bromide and lithium bromide in mixed aqueous solvent systems.J. Phys. Chem., 76, 3050–3057 (1972).

    Article  CAS  Google Scholar 

  • Miyazaki, S., Nakamura, T., and Takada, M., Thermo-sensitive sol-gel transition of pluronic F-127.Yakuzaigaku, 51, 36–43 (1991).

    CAS  Google Scholar 

  • Miyazaki, S., Nakamura, T., Yokouchi, C., and Takada, M., Effect of pluronic gels on the rectal absorption of indomethacin in rabbits.Chem. Pharm. Bull., 35, 1243–1248 (1987).

    PubMed  CAS  Google Scholar 

  • Mortensen, K. and Pederson, J. S., Structural study on the micelle formation of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer in aqueous solution.Macromolecules, 26, 805–812 (1993).

    Article  CAS  Google Scholar 

  • Mortensen, K., Block copolymer in aqueous solution: Micelle formation and hard-sphere crystallization.Progr. Colloid Polym. Sci., 93, 72–75 (1993).

    Article  CAS  Google Scholar 

  • Osborne, D. W. and Amann, A. H.,Topical Drug Delivery Formulations, Marcel Dekker, New York, U.S.A., pp. 381–388 (1990).

    Google Scholar 

  • Pandit, N. K. and Kisaka, J., Loss of gelation ability of Pluronic F127 in the presence of some salts.Int. J. Pharm., 145, 129–136 (1996).

    Article  CAS  Google Scholar 

  • Pandit, N. K. and Wang, D., Salt effects on the diffusion and release rate of propranolol from poloxamer 407 gels.Int. J. Pharm., 167, 183–189 (1998).

    Article  CAS  Google Scholar 

  • Pisal, S. S., Paradkar, A. R., Mahadik, K. R., and Kadam, S. S., Pluronic gels for nasal delivery of Vitamin B12. Part I: Preformulation study.Int. J. Pharm., 270, 37–45 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Prancan, A. V., Ecanow, B., Bernardoni, R. J., and Sadove, M.S., Poloxamer 188 as vehicle for injectable diazepam.J. Pharm. Sci., 69, 970–971 (1980).

    Article  PubMed  CAS  Google Scholar 

  • Rassing, J. and Attwood, D., Ultrasonic velocity and light-scattering studies on the polyoxyethylene-polyoxypropylene copolymer Pluronic F127 in aqueous solution.Int. J. Pharm., 13, 47–55 (1983).

    Article  Google Scholar 

  • Rassing, J., Mckenna, W. P., Bandyopadhyay, S., and Eyring, E. M., Ultrasonic and13C-NMR studies on gel formation in aqueous solutions of the ABA block polymer Pluronic F127.J. Molecul. Liq., 27, 165–178 (1984).

    CAS  Google Scholar 

  • Reddy, R. K., Khalil, S. A., and Gouda, M. W., Dissolution characteristics and oral absorption of digitoxin and digoxin coprecipitates.J. Pharm. Sci., 65, 1753–1757, (1976).

    Article  PubMed  CAS  Google Scholar 

  • Reddy, R. K., Khalil, S. A., and Gouda, M. W., Effect of dioctyl sodium sulfosuccinate and poloxamer 188 on dissolution and intestinal absorption of sulfadiazine and sulfisoxazole in rats.J. Pharm. Sci., 65, 115–117 (1976).

    Article  PubMed  CAS  Google Scholar 

  • Ruel-Gariépy, E. and Leroux, J. C., In situ-forming hydrogels-review of temperature-sensitive systems.Eur. J. Pharm. Biopharm., 58, 409–426 (2004).

    Article  PubMed  Google Scholar 

  • Schillén, K., Glatter, O., and Brown, W., Characterization of a PEO-PPO-PEO block copolymer system.Progr. Colloid Polym. Sci., 93, 66–71 (1993).

    Article  Google Scholar 

  • Schmolka, I. R., Artificial skin i: Preparation and properties of Pluronic F-127 gels for the treatment of burns.J. Biomed. Mater. Res., 6, 571 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Tanodekaew, S., Deng, N. J., Smith, S., Yang, Y. W., Attwood, D., and Booth, C., Micellization and gelation of block-copoly (oxyethylene/oxybutylene) in aqueous solution.J. Phys. Chem., 97, 11847–11852 (1993).

    Article  CAS  Google Scholar 

  • Tanodekaew, S., Godward, J., Heatley, F., and Booth, C., Gelation of aqueous solutions of diblock copolymers of ethylene oxide and D,L-lactide.Macromol. Chem. Phys., 198, 3385–3395 (1997).

    Article  CAS  Google Scholar 

  • Vemohr, H. and Borchard, W., Investigation of the thermoreversible gelation of gelatin/water and determination of the gel-point.Proc. XIIth Int. Congr. on Rheology, August 18–23 (1996).

  • Viegas, T. X. and Henry, R. L., Osmotic behavior of poloxamer 407 and other non-ionic surfactants in aqueous solution.Int. J. Pharm., 160, 157–162 (1998).

    Article  CAS  Google Scholar 

  • Wanka, G., Hoffmann, H., and Ulbricht, W., The aggregation behavior of poly-(oxyethylene)-poly-(oxypropylene)-poly-(oxythylene)-block-copolymers in aqueous solution.Colloid Polym. Sci., 268, 101–117 (1990).

    Article  CAS  Google Scholar 

  • Yong, C. S., Oh, Y. K., Jung, S. H., Rhee, J. D., Kim, H. D., Kim, C. K., and Choi, H. G., Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol.Eur. J. Pharm. Sci., 23, 347–353 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Yong, C. S., Yang, C. H., Rhee, J. D., Lee, B. J., Kim, D. C., Kim, D. D., Kim, C. K., Choi, J. S., and Choi, H. G., Enhanced rectal bioavailability of ibuprofen in rats by poloxamer 188 and menthol.Int. J. Pharm., 269, 169–176 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Zhou, Z. and Chu, B., Anomalous association behavior of an ethylene oxide/propylene oxide ABA block copolymer in water.Macromolecules, 20, 3089–3091 (1987).

    Article  CAS  Google Scholar 

  • Zhou, Z. and Chu, B., Light-scattering study on the association behavior of triblock polymers of ethylene oxide and propylene oxide in aqueous solution.J. Colloid Interface Sci., 126, 171–180 (1988).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Pharmacy, Sungkyunkwan University, 440-746, Suwon, Korea

    Yun-Seok Rhee, Young-Hee Shin, Chun-Woong Park, Sang-Cheol Chi & Eun-Seok Park

Authors
  1. Yun-Seok Rhee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Young-Hee Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chun-Woong Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sang-Cheol Chi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Eun-Seok Park
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eun-Seok Park.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rhee, YS., Shin, YH., Park, CW. et al. Effect of flavors on the viscosity and gelling point of aqueous poloxamer solution. Arch Pharm Res 29, 1171–1178 (2006). https://doi.org/10.1007/BF02969310

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02969310

Key words

Search

Navigation