Abstract
The methanol extract from the aerial parts ofDictamnus albus was active in inhibiting monoamine oxidase (MAO) from the mouse brain. Activity-guided fractionation led to the isolation of four known coumarins, 7-(6′R-hydroxy-3′, 7′-dimethyl-2′E, 7′-octadienyloxy) coumarin (1), auraptene (2), umbelliferone (3), and xanthotoxin (4), as active compounds along with an inactive alkaloid, skimmianine (5). Compounds1 and2 inhibited MAO activity in a concentration-dependent manner with IC50 values of 0.7 and 1.7 μM, respectively. Compounds1 and2 showed a slight and potently selective inhibitory effect against MAO-B (IC50 0.5 and 0.6 μM, respectively) compared to MAO-A (IC50 1.3 and 34.6 μM, respectively). According to kinetic analyses derived by Lineweaver-Burk reciprocal plots, compounds1 and2 exhibited a competitive inhibition to MAO-B.
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Jeong, S.H., Han, X.H., Hong, S.S. et al. Monoamine oxidase inhibitory coumarins from the aerial parts ofDictamnus albus . Arch Pharm Res 29, 1119–1124 (2006). https://doi.org/10.1007/BF02969302
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DOI: https://doi.org/10.1007/BF02969302