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Archives of Pharmacal Research

, Volume 29, Issue 12, pp 1102–1108 | Cite as

Anti-inflammatory activity of flavonoids fromPopulus davidiana

  • XinFeng Zhang
  • Tran Manh Hung
  • Phuong Thien Phuong
  • Tran Minh Ngoc
  • Byung-Sun Min
  • Kyung-Sik Song
  • Yeon Hee Seong
  • KiHwan BaeEmail author
Articles Drug Design

Abstract

Anin vitro bioassay-guide revealed that the methanol (MeOH) extract of the stem bark ofPopulus davidiana showed considerable inhibitory activity against cyclooxygenase (COX-1, COX-2). Continuous phytochemical study of the MeOH extract of this plant led to the isolation of ten flavonoids; sakuranetin (1), rhamnocitrin (2), 7-O-methylaromadendrin (3), naringenin (4), eriodictyol (5), aromadendrin (6), kaempferol (7), neosakuranin (8), sakuranin (9) and sakurenetin-5,4′-di-β-D-glucopyranoside (10). Their structures were identified on the basis of their physicochemical and spectroscopic analyses. The isolated compounds,1–10, were tested for their inhibitory activities against COX-1 and COX-2. Compound7 was found to have potent inhibitory effect on COX-1 and a moderate effect on COX-2, meanwhile, compounds1–6 showed moderate inhibition against COX-1 only. Moreover, compounds5–8 exhibited suppressive effects on xanthine oxidase (XO). These results may explain, in part, the traditional uses ofP. davidiana in ethnomedicine.

Key words

Populus davidiana Flavonoids Anti-inflammatory Cyclooxygenase Xanthine oxidase 

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Copyright information

© The Pharmaceutical Society of Korea 2006

Authors and Affiliations

  • XinFeng Zhang
    • 1
  • Tran Manh Hung
    • 1
  • Phuong Thien Phuong
    • 1
  • Tran Minh Ngoc
    • 1
  • Byung-Sun Min
    • 2
  • Kyung-Sik Song
    • 3
  • Yeon Hee Seong
    • 4
  • KiHwan Bae
    • 1
    Email author
  1. 1.College of PharmacyChungnam National UniversityDaejeonKorea
  2. 2.College of PharmacyCatholic University of DaeguGyeongbukKorea
  3. 3.College of Agriculture and Life ScienceKyungbuk National UniversityDaeguKorea
  4. 4.College of Veterinary MedicineChungbuk National UniversityCheonjuKorea

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