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Expression muqueuse de ľinterleukine 1β dans Ia colite ulcéreuse — quantification par PCR —

Mucosal expression of interleukin 1β in ulcerative colitis — quantification by PCR —

Expresión mucosa de la interleukina 1βen la colitis ulcerativa — cuantificación por PCR —

  • Published:
Acta Endoscopica

Résumé

Ľinterleukine-1β est une cytokine impliquée dans de multiples processus inflammatoires. Récemment, une induction précoce de ľinterleukine-1β a été mise en évidence sur différents modèles animaux de colite ulcéreuse. Nous avons investigué ľexpression du gène interleukine-lβ sur des biopsies prélevées chez des patients atteints de colite ulcéreuse et des témoins, en utilisant une technique ďADN-amplification. Nos résultats montrent qu’au niveau de la muqueuse de colite ulcéreuse, les taux ďinterleukine-1β sont augmentés.

Summary

Interleukin-1β is a cytokine that is implicated in many inflammatory processes. Recently, early induction of interleukin-1β has been demonstrated in several animal models of ulcerative colitis. We have now investigated expression of the interleukin-1β gene in biopsy specimens obtained from ulcerative colitis patients and controls, using a DNA-amplification technique. Our results indicate that in ulcerative colitis mucosal levels of interleukine-β are increased.

Resumen

La interleukina 1β es una citokina implicada en múltiples procesos inflamatorios. Recientemente una inducción precoz de interleukina 1β ha sido puesta en evidencia sobre diferentes modelos animales de colitis ulcerativa. Nosotros hemos investigado la expresión del gene interleukina 1β en biopsias tornados en pacientes con colitis ulcerativa y en testigos, utilizando una técnica de ADN-amplificacién, Nuestros resultados muestran que a nivel de la mucosa de colitis ulcerativa, los niveles de interleukina 1β están aumentadas.

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Authors and Affiliations

  1. Academish Medisch Centrum, Amsterdam, Netherlands

    J. H. Van deventer, S. A. Radema, J. F. W. M. Bartelsman & G. N. J. Tytgat

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  1. J. H. Van deventer
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  2. S. A. Radema
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  3. J. F. W. M. Bartelsman
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  4. G. N. J. Tytgat
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Van deventer, J.H., Radema, S.A., Bartelsman, J.F.W.M. et al. Expression muqueuse de ľinterleukine 1β dans Ia colite ulcéreuse — quantification par PCR —. Acta Endosc 21, 249–254 (1991). https://doi.org/10.1007/BF02968713

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  • DOI: https://doi.org/10.1007/BF02968713

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