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Les cytokines dans la colite ulcéreuse et la maladie de Crohn

Cytokines in ulcerative colitis and Crohn’s disease

Las citokinas en la colitis ulcerativa y en la Enfermedad de Crohn

  • Published:
Acta Endoscopica

Résumé

Les cytokines sont des facteurs solubles libérés suite à ľactivation des cellules immunitaires, en particulier les macrophages et les lymphocytes. Ces cytokines influencent les cellules immunocompétentes en contrôlant leur différentiation, activation et prolifération. Une hypothése pouvant éclairer la pathogenèse des maladies inflammatoires pourrait être la libération inadéquate de cytokines responsable d’un déficit du contrôle immunorégulateur.

Summary

Activation of immune cells, especially macrophages and lymphocytes, releases a series of soluble factors (cytokines) which act on neighbouring cells to control differentiation, activation and proliferation. One hypothesis for the pathogenesis of inflammatory bowel disease could be that abnormal release of cytokines might result in disordered immunoregulation.

Resumen

Las citokinas son factores solubles liberados como consecuencia de la activación de las células inmunitarias, en particular los macrófagos y los linfocitos. Estas citokinas actüan sobre las células inmunocompetentes controlando su diferenciación, activación y proliferación. Una hipótesis que podría aclarar la patogénesis de las enfermedades inflamatorias podría ser la liberación inadecuada de citokinas responsables de un déficit del control inmuno-regulador.

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Références

  1. BAKER K., JEWELL D.P. — Cyclosporin for the Treatment of Severe Inflammatory Bowel Disease.Aliment Pharmacol.Thera, 1989, 143–149.

    Google Scholar 

  2. DINARELLO C.A. — Interleukin-1.Dig. Dis. Sci., 1988, 33, No 3, 25S-35S.

    Article  PubMed  CAS  Google Scholar 

  3. DINARELLO C.A., MIER J.W. — Current Concepts Lymphokines.N. Eng. J. Med., 1987, Vol. 317, 15, 940–945.

    CAS  Google Scholar 

  4. FIOCCHI C., YOUNGMAN K.R., YEN-LIEBERMAN B., TUBBS R.R. — Modulation of Intestinal Immune Reactivity by Interleukin 2.Dig. Dis. Sci., 1988, Vol. 33, 10, 1305–1315.

    Article  PubMed  CAS  Google Scholar 

  5. FIOCCHI C., HILFIKER M.L., YOUNGMAN K.R., DOERDER N.C., FINKE J.H. — Interleukin 2 Activity of Human Intestinal Mucosa Mononuclear Cells. Decreased Levels in Inflammatory Bowel Disease. Gastroenterology, 1984, 86, 734–42.

    PubMed  CAS  Google Scholar 

  6. FIOCCHI C., LEVINE A.D., WEST G.A., YOUNGMAN K.R. — Interleukin 4 (IL4) Modulates Proliferative and Cytotoxic Responses of Human Intestinal Mucosal Mononuclear Cells.Gastroenterology, 1989, Vol. 96, 5, A152.

    Google Scholar 

  7. ISAACS K., SARTOR R.B., WANG A., HASKILL J.S. — Profiles of Cytokine Activation in Inflammatory Bowel Disease Tissue: Measurement by cDNA Amplification.Gastroenterology, 1990, Vol. 98, 5 (2), A455.

    Google Scholar 

  8. KONTTINEN Y.T., BERGROTH V., NORDSTROM D., SEGERBERG-KONTTINEN., SEPPALA K., SALASPURO M. — Lymphocyte Activation in vivo in the Intestinal Mucosa of Patients with Crohn’s Disease.j. Clin. Lab. Immunol., 1987, 22, 59–63.

    PubMed  CAS  Google Scholar 

  9. LIEBERMAN B.Y., FIOCCHI C., YOUNGMAN K.R., SAPATNEKAR W.K., PROFFITT M.R. — Interferon -γ Production by Human Intestinal Mucosal Mononuclear Cells. Decreased Levels in Inflammatory Bowel Disease.Dig. Dis. Sci., 1988, Vol. 33, 10, 1297–1304.

    Article  PubMed  CAS  Google Scholar 

  10. KUSUGAMI K., YOUNGMAN K.R., WEST G.A., FIOCCHI C. — Intestinal Immune Reactivity to Interleu- kin 2 Differs Among Crohn’s Disease, Ulcerative Colitis, and Controls.Gastroenterology, 1989, 97, 1–9.

    PubMed  CAS  Google Scholar 

  11. LOWES J.R., RADWAN P., PRIDDLE J.D., JEWELL D.P. — Induction of HLA-DR Molecules on a Colonic Epithelial Cell Line by γ-Interferon (γ-IFN).Clin. Sci., 1988, Vol. 74 (suppl 18) 31 p, A 116.

    Google Scholar 

  12. LOWES J.R., PRIDDLE J.D., JEWELL D.P. — Production of Epithelial Cell Growth Factors by Lamina Propria Mononuclear Cells (LPMNC).Gut., 1989, Vol. 30, 10, A1449.

    Google Scholar 

  13. MCDONALD G.B., JEWELL D.P. — Class II Antigen (HLA-DR) Expression by Intestinal Epithelial Cells in Inflammatory Diseases of Colon.j. Clin. Pathol., 1987, 40, 312–317.

    Article  PubMed  CAS  Google Scholar 

  14. MAHIDA Y.R., PATEL S., GIONCHETTI P., VAUX D., JEWELL D.P. — Macrophage Subpopulations in Lamina Propria of Normal and Inflamed Colon and Terminal Ileum.Gut., 1989, Vol. 30, 6, 826–834.

    Article  PubMed  CAS  Google Scholar 

  15. MAHIDA Y.R., WU K., JEWELL D.P. — Enhanced Production of Interleukin l-β by Mononuclear Cells Isolated from Mucosa with Active Ulcerative Colitis of Crohn’s Disease.Gut., 1989, Vol. 30, 6, 835–838.

    Article  PubMed  CAS  Google Scholar 

  16. MALKOVSKY M., SONDELL P.M., STROBER W., DALGLEISH A.G. — Review: The Interleukins in Acquired Disease.Clin. exp. Immunol., 1988, 74, 151–161.

    PubMed  CAS  Google Scholar 

  17. MEE A.S., SZAWATAKOWSKI M., JEWELL D.P. — Monocytes in Inflammatory Bowel Disease: Phagocytosis and Intracellular Killing.j. Clin. Pathol., 33, 921-925.

  18. PULLMAN W., HAPEL A.J., DOE W.F. — Colony Stimulating Factor Production by Intestinal Lamina Propria Cells is Increased in Inflammatory Bowel Disease (IBD).Gastroenterology, 1988, Vol. 94, 5, A361.

    Google Scholar 

  19. ROSSITER G., PODOLSKY D.K. — Expression of Transforming Growth Factor Alpha and Beta in Colonic Mucosa in Ulcerative Colitis.Gastroenterology, 1990, Vol. 98, 5 (2), A471.

    Google Scholar 

  20. SATSANGI J., WOLSTENCROFT R.A., CASON J., AINLEY C.C., DUMONDE D.C., THOMPSON R.P.H. — Interleukin 1 in Crohn’s Disease.Clin. exp. Immunol., 1987, 67, 594–605.

    PubMed  CAS  Google Scholar 

  21. SELBY W.S., JANOSSY G., GOLDSTEIN G., JEWELL D.P. — T Lymphocyte Subsets in Human Intestinal Mucosa: the Distribution and Relationship to MHC-Derived Antigens.Clin. exp. Immunol., 1981, 44, 453–458.

    PubMed  CAS  Google Scholar 

  22. SOLLID L.M., GAUDERNACK G., MARKUSSEN G., KVALE D., BRANDTZAEG P., THORSBY E. — Induction of Various HLA Class II Molecules in a Human Colonic Adenocarcinoma Cell Line.Scan. J. Immunol, 1987, 25, 175–180.

    Article  CAS  Google Scholar 

  23. STEVENS C., WALZ G., ZANKER B., SINGARAM C., LIPMAN M., STROM T.B. — Interleukin-6 (IL-6), Inter- leukin-1 Beta (IL-lβ) and Tumour Necrosis Factor Alpha (TNFα) Expression in Inflammatory Bowel Disease (IBD).Gastroenterology, 1990, Vol. 98, 5 (2), A475.

    Google Scholar 

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  1. Gastroenterology Unit, Radcliffe Infirmary, Oxford, U.K.

    P. Hoang & D. P. Jewell

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  1. P. Hoang
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  2. D. P. Jewell
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Hoang, P., Jewell, D.P. Les cytokines dans la colite ulcéreuse et la maladie de Crohn. Acta Endosc 21, 233–238 (1991). https://doi.org/10.1007/BF02968711

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  • DOI: https://doi.org/10.1007/BF02968711

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