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Les œsophagites « primitives » ďorigine médicamenteuse a propos de 978 observations (1970-1990)

« Primitive » drug-induced oesophagitis. about 978 observations (1970-1990)

Las esofagitis « primitivas » de origen medicamentoso. a proposito de 978 observaciones (1970-1990)

  • Published:
Acta Endoscopica

Résumé

La prévalence et ľincidence des œsophagites directement induites par des médicaments sont probablement sous-estimées. Les principaux agents responsables sont les antibiotiques, le bromure ďémépronium et les anti-inflammatoires. Le principal facteur favorisant est ľingestion du médicament sans eau et/ou de sa prise en position allongée. Ľendoscopie est indispensable pour le diagnostic; elle révèle habituellement des érosions localisées au niveau des deux-tiers supérieurs de ľœsophage. Ľévolution des lésions œsophagiennes est généralement favorable aprés ľarrêt du médicament incriminé. Des complications graves (sténose, perforation, hémorragie), parfois mortelles (6 cas), ne sont pas exceptionnelles.

Summary

The prevalence and incidence of oesophagitis directly caused by drug is probably underestimated. The principal causal agents are the antibiotics, emepronium bromide and the anti-inflammatory drugs. The principal propitious factor is the ingestion of the drug without water and/or in a reclining position. Endoscopy is essential for the diagnosis; it usually reveals localized erosions in the upper two thirds of the oesophagus. The evolution of these oesophageal erosions is generally favourable, as soon as the incriminated medication is withdrawn. However, serious complications (stenosis, perforation, haemorrhage), and sometimes even death (6 cases), are not exceptional.

Resumen

La prevalencia y la incidencia de esofagitis directamente inducida por medicamentos estan probablemente sub-estimadas. Los principales agentes responsables son los antibióticos, el bromuro de emepronio y los anti-inflamatorios. El principal factor favorecedor es la ingestión del medicamento sin agua y/o su toma en posición horizontal. La endoscopia es indispensable para el diagnóstico; ella revela habitualmente las erosiones localizadas a nivel de los dos tercios superiores del esófago. La evolución de la lesiones esofágicas es generalmente favorable después de suspender el medicamento incriminado. Complicaciones graves (estenosis, perforación, hemorragia), algunas veces mortales (6 casos), no son excepcionales.

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Authors and Affiliations

  1. Institut Universitaire de Pathologie, Bugnon 25, Lausanne, Suisse

    J. -B. Ollyo, Ch. Fontolliet, E. Brossard & Ph. Monnier

  2. Dépt. de Chirurgie, Centre Hospitalier Universitaire Vaudois, Lausanne, Suisse

    J. -B. Ollyo, J. Wellinger, E. Brossard & Ph. Monnier

  3. Service ORL, CHUV, Lausanne, Suisse

    J. -B. Ollyo, E. Brossard & Ph. Monnier

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  1. J. -B. Ollyo
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  2. Ch. Fontolliet
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  4. E. Brossard
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Ollyo, J.B., Fontolliet, C., Wellinger, J. et al. Les œsophagites « primitives » ďorigine médicamenteuse a propos de 978 observations (1970-1990). Acta Endosc 21, 671–680 (1991). https://doi.org/10.1007/BF02968564

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