Abstract
Four known butenolides were isolated from the ethyl acetate extracts of the culture broth of the marine-derived bacterium,Streptoverticillum luteoverticillatum, by bioassay-guided fractionation. The structures were identified on the basis of spectral data. The absolute configuration of compound (1) was determined by CD spectrum for the first time. Compounds1–4 showedin vitro cytotoxicity against the murine lymphoma P388 and human leukemia K562 cell lines. This is the first report on the isolation of butenolides from the marine bacterium,Streptoverticillium luteoverticillatum, and their cytotoxic activities.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Blunt, J. W., Copp, R. C., Munro, M. H. G., Northcote, P. T., and Prinsep, M. R., Marine natural products,Nat. Prod. Rep., 22, 15–64 (2005).
Braun, D., Pauli, N., Sequin, U., and Zahner, H., New butenolides from the photoconductivity screening ofStreptomyces antibioticus (Waksman and Woodruff) Waksman and Henrici 1948.FEMS Microbiol. Lett., 126, 37–42 (1995).
Cho, K. W., Lee, H. S., Rho, J. R., Kim, T. S., Mo, S. J., and Shin, J., New lactone-containing metabolites from a marine-derived bacterium of the genusStreptomyces, J. Nat. Prod., 64, 664–667 (2001).
Mukku, V. J. R. V., Speitling, M., Laatsch, H., and Helmke, E., New butenolides from two marine streptomycetes.J. Nat. Prod., 63, 1570–1572 (2000).
Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer drug screening,J. Natl Cancer Inst., 82, 1107–1112 (1990).
Tayyab, A. Manssor, Jongki Hong, Chong-O. Lee, Chung Ja Sim, Kwang Sik Im, Dong Seok Lee, and Jee H. Jung, New cytotoxic metabolites from a marine spongeHomaxinella sp.J. Nat. Prod., 67, 721–724 (2004).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Li, D.H., Zhu, T.J., Liu, H.B. et al. Four butenolides are novel cytotoxic compounds isolated from the marine-derived bacterium,Streptoverticillium luteoverticillatum 11014. Arch Pharm Res 29, 624–626 (2006). https://doi.org/10.1007/BF02968245
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02968245