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Severe infusion reaction induced by trastuzumab: A case report

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Abstract

We report a case of a severe infusion reaction caused by trastuzumab. A 59-year-old woman with metastatic breast cancer was treated with trastuzumab. During the first infusion, initial symptoms such as severe headache and general fatigue developed. Blood pressure fell 90 minutes after these initial symptoms. A collapsed lung was demonstrated by chest X-ray and computed tomography. Steroid therapy was successfully used for these reactions. Careful monitoring of vital signs, examination of the respiratory system, and the use of steroids are recommended for severe infusion reaction.

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Authors and Affiliations

  1. Department of Medical Oncology, Japan

    Keiichiro Tada, Yoshinori Ito, Kiyohiko Hatake, Taeko Okudaira, Jun-ichiro Watanabe, Masahiro Arakawa, Masayo Miyazato, Tetsuya Irie, Nobuyuki Mizunuma, Syunji Takahashi, Keisuke Aiba & Noboru Horikoshi

  2. Department of Breast Surgery, Cancer Institute Hospital, Japan

    Fujio Kasumi

Authors
  1. Keiichiro Tada
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  2. Yoshinori Ito
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  3. Kiyohiko Hatake
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  4. Taeko Okudaira
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  5. Jun-ichiro Watanabe
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  6. Masahiro Arakawa
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  7. Masayo Miyazato
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  8. Tetsuya Irie
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  9. Nobuyuki Mizunuma
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  10. Syunji Takahashi
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  11. Keisuke Aiba
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  12. Noboru Horikoshi
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  13. Fujio Kasumi
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Corresponding author

Correspondence to Keiichiro Tada.

Additional information

Reprint requests to Keiichiro Tada, Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 170-8455, Japan.

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Tada, K., Ito, Y., Hatake, K. et al. Severe infusion reaction induced by trastuzumab: A case report. Breast Cancer 10, 167–169 (2003). https://doi.org/10.1007/BF02967644

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  • DOI: https://doi.org/10.1007/BF02967644

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