Abstract
To characterize the effect that inactivation of a putative tumor suppressor gene on 6q appears to have on breast carcinogenesis, we examined loss of heterozygosity in 528 primary breast carcinomas with a polymorphic marker located at 6q26-27, a frequent target region of allelic loss in ovarian and breast cancers. Of the 56 informative tumors of the solid-tubular type, 29 (52%) showed allelic loss at 6q26-27; however, only 10 of 42 papillotubular carcinomas (23%) and 34 of 86 scirrhous carcinomas (39%) showed allelic loss (p=0.0215). These results are consistent with reported alterations at 6q26-27 in serous and mucinous types of ovarian cancers, in that they suggest that inactivation of one or more genes in that region may affect carcinogenic mechanisms in a histologic type-specific manner in neoplasms of the female reproductive organs.
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Abbreviations
- LOH:
-
Loss of heterozygosity
- PCR:
-
Polymerase chain reaction
- ER:
-
Estrogen receptor
- PgR:
-
Progesterone receptor
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Bando, K., Matsumoto, S., Onda, M. et al. Frequent Allelic Loss at 6q26-27 in Breast Carcinomas of the Solid-tubular Histologic Type. Breast Cancer 5, 127–130 (1998). https://doi.org/10.1007/BF02966684
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DOI: https://doi.org/10.1007/BF02966684