Skip to main content
SpringerLink
Log in

Prognostic significance of the urokinase type plasminogen activator (u-PA) system in node-negative breast cancer

  • Published:
Breast Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

u-PA:

Urokinase type plasminogen activator

t-PA:

Tissue type plasminogen activator

PAI-1:

Plasminogen activator inhibitor-1

u-PAR:

Urokinase type plasminogen activator receptor

References

  1. Mullins DE, Rohrlich ST: The role of proteinases in cellular invasiveness.Biochim Biophys Acta 695:177–214, 1983.

    PubMed  CAS  Google Scholar 

  2. Schmitt M, Janicke F, Graeff H: Tumor-associated fibrinolysis; The prognostic relevance of plasminogen activators uPA and tPA in human breast cancer.Blood Coagul Fibrinolysis 1:695–702, 1990

    PubMed  CAS  Google Scholar 

  3. Murphy G, Willenbrock F, Crabbe T.et at: Regulation of matrix metalloproteinases.Ann N Y Acad Sci 723:31–41, 1994.

    Google Scholar 

  4. Duffy MJ: Urokinase-type plasminogen activator and malignancy.Fibrinolysis 7:293–303, 1993.

    Article  Google Scholar 

  5. Grondahl-Hansen J, Christensen IJ, Rosenquist C,et al: High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis.Cancer Res 53:2513–2521, 1993.

    PubMed  CAS  Google Scholar 

  6. Gray R, Clarke M, Collins R,et al: The EBCTCG overview of adjuvant therapy of breast cancer; What are the implications for future studies? Early Breast Cancer Trialists’ Collaborative Group.Ann N Y Acad Sci 698:339–348, 1993.

    Article  PubMed  CAS  Google Scholar 

  7. Shiba E, Kim SJ, Taguchi T,et al: A prospective study on the prognostic significance of urokinase-type plasminogen activator levels in breast cancer tissue.J Cancer Res Clin Oncol 123:555–559, 1997.

    Article  PubMed  CAS  Google Scholar 

  8. Kim SJ, Shiba E, Kobayashi T,et al: Prognostic impact of urokinase-type plasminogen activator (PA), PA inhibitor type-1, and tissue-type PA antigen levels in node-negative breast cancer; A prospective study on multicenter basis.Clin Cancer Res 4:177–182, 1998.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical Oncology, Osaka University Medical School, Osaka

    Eiichi Shiba, Seung Jin Kim, Tetsuya Taguchi, Fumine Tsukamoto & Shinzaburo Noguchi

Authors
  1. Eiichi Shiba
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seung Jin Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tetsuya Taguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Fumine Tsukamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Shinzaburo Noguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Shiba, E., Kim, S.J., Taguchi, T. et al. Prognostic significance of the urokinase type plasminogen activator (u-PA) system in node-negative breast cancer. Breast Cancer 6, 357–360 (1999). https://doi.org/10.1007/BF02966453

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02966453

Key words

Search

Navigation