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Apport de ľhistochimie des mucines à ľétude et au diagnostic des conditions et lésions précancéreuses de la muqueuse gastrique

The contribution of mucin histochemistry to the study and diagnosis of precancerous conditions and lesions of the gastric mucosa

Aporte de la histoquimia de las mucinas al estudio y diagnostico de los estadios y lesiones precancerosas de la mucosa gástrica

  • Published:
Acta Endoscopica

Résumé

Ľauteur présente une revue des principes et de ľapport récent de ľhistochimie des mucines à ľétude et au diagnostic des lésions précancéreuses de la muqueuse gastrique. Les méthodes histochimiques courantes de mise en évidence des mucines sont évaluées. Les caractères essentiels du profil des mucines dans la métaplasie intestinale, dans ľœsophage de Barrett, dans les moignons de gastrectomies et dans les polypes adénomateux sont décrits. Les corrélations possibles entre ľhistochimie des mucines et certains aspects anatomo-cliniques de ces lésions précancéreuses sont discutées.

Summary

The author presents a review of the principles and recent contribution of mucin histochemistry to the study and diagnosis of precancerous lesions of the gastric mucosa. The current histochemical methods for mucin identification are assessed. The relevant aspects of the mucin profile found in intestinal metaplasia, Barrett’s oesophagus, gastric stump and adenomatous polyps are described. Possible correlations between mucin histochemistry and certain clinico-pathological features of these precancerous lesions are discussed.

Resumen

El autor presenta una revisión de los principios y de las aportaciones recientes de los estudios histoquimicos de las mucinas en el estudio y diagnostico de las lesiones precancerosas de la mucosa gástrica. Se evaluan los métodos histoquimicos habituales que demuestran la presencia de mucinas. Se describen los caracteres esenciales del perfil de las mucinas que se detectan en la metaplasia intestinal, en el esófago de Barrett, en los muñones de gastrectomia y en los pólipos adenomatosos. Se discuten las posibles correlaciones entre la histoquimia de las mucinas y ciertos aspectos anatomoclinicos de las mencionadas lesiones precancerosas.

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Authors and Affiliations

  1. Laboratoire ďAnatomie Pathologique, Institut Jean-Godinot, Boîte postale 171, F-51056, Reims Cedex, France

    W. V. Bogomoletz

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Bogomoletz, W.V. Apport de ľhistochimie des mucines à ľétude et au diagnostic des conditions et lésions précancéreuses de la muqueuse gastrique. Acta Endosc 18, 5–14 (1988). https://doi.org/10.1007/BF02965010

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