Concerns about the association of aseptic meningitis with measles-mumpsrubella (MMR) vaccines containing the Urabe Am 9 strain and the increasing worldwide demand for MMR vaccines, prompted the development of a new mumps vaccine strain (RIT 4385) by SmithKline Beecham Biologicals (SB) as part of a trivalent live attenuated MMR vaccine. The present study assessed the immunogenicity and reactogenicity of two lots of ‘Priorix’* with a widely used and established vaccine M-M-R II (Merck & Co. Inc.) as comparator vaccine. 255 healthy children, 12 to 24 months of age, were enrolled in a single-blind study and randomly allocated to receive a single dose of one of two lots of “Priorix” or M-M-R II vaccine. Vaccinees were followed up for six weeks post-vaccination for solicited and unsolicited symptoms. Immunogenicity was determined in pre- and 60 days post-vaccination sera using commercial immunoassays for measles, mumps and rubella antibodies. There were no significant differences in immune responses between groups for any of the three vaccine components. In initially seronegative subjects, the respective post-vaccination seroconversion rates for ‘Priorix’ lots 1 and 2, and M-M-R II were 100, 100 and 97.6% for measles antibodies, 91.7, 95.1 and 94% for mumps antibodies and 100, 100 and 100% for rubella antibodies, respectively. GMTs for the three groups were 3,076, 3,641 and 3,173 mIU/ml for measles antibodies, 934, 900 and 1,043 U/ml for mumps antibodies, and 86.4, 87.5 and 97.1 IU/ml for rubella antibodies, respectively. The incidence of local symptoms was significantly lower for both ‘Priorix’ lots (17.6 and 15.3% for lots 1 and 2, respectively) than for M-M-R II (37.6%). Fever≧38.1°C during the six-week observation period occurred in approximately 25% of all subjects in all groups with no differences between the groups. No parotid/salivary gland swelling or signs of suspected meningism were reported, and there were no serious adverse events related to vaccination. The new MMR vaccine ‘Priorix’ containing the new RIT 4385 mumps strain was safe and had a significantly improved local tolerability profile over the comparator vaccine, M-M-R II, while eliciting an at least equivalent immune response.
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World Health Organization: Expanded programme on immunisation: a report from the programme on communicable diseases. WHO, Copenhagen 1989, pp. 10–13.
Nokes, D. J., Anderson, R. M.: Application of mathematical models to the design of immunisation strategies. Rev. Med. Microbiol. 4 (1993) 1–7.
Bundesamt für Gesundheitswesen: Masern-, Mumps-, Röteln-Impfung: Empfehlung des Bundesamtes für Gesundheitswesen. Bull. BAG 38 (1994), 650–651.
Hilleman, M. R.: The development of live attenuated mumps virus vaccine in historic perspective and its role in the evolution of combined measles-mumps-rubella. In:Plotkin, S., Fantini, B. (eds.). Vaccinia vaccination, and vaccinology: Jenner, Pasteur and their successors. Elsevier, Paris 1996, pp. 283–292.
Peltola, H., Heinonen, O. P., Valle, M., Paunio, M., Virtanen, M., Karanko, V., Cantell, K.: The elimination of indigenous measles, mumps and rubella from Finland by a 12-year two-dose vaccination programme. N. Engl. J. Med. 331 (1994) 1397–1402.
Cochi, S. L., Wharton, M., Plotkin, S. A.: Mumps vaccine. In:Plotkin, S. A., Morimer, E. A., (eds.). Vaccines, Saunders, Philadelphia, 1994, pp. 277–301.
White, C., Koplan, J., Orenstein, W.: Benefits, risks, and costs of immunisation for measles, mumps and rubella. Am. J. Public Health 75 (1985) 739–744.
Anonymous: Mumps meningitis and MMR vaccination. Lancet ii (1989) 1015–1016.
Miller, E., Goldacre, M., Pugh, S., Colville, A., Farrington, P., Flower, A., Nash, J., MacFarlane, L., Tettmar, R.: Risk of aseptic meningitis after measles, mumps and rubella vaccine in UK children. Lancet 341 (1993) 979–982.
Balraj, V., Miller, E.: Complications of mumps vaccines. Rev. Med. Virol. 5 (1995), 219–227.
Takeuchi, K., Tanabyashi, K., Hishiyama, M., Yamada, A., Sugiura, A.: Variations of nucleotide sequences and transcription of the SH gene among mumps virus strains. Virology 181 (1991) 364–366.
Afzal, M. A., Pickford, A. R., Forsey, T., Heath, A. B., Minor, P. D.: The Jeryl Lynn vaccine strain of mumps virus is a mixture of two distinct isolates. J. Gen. Virol. 74 (1993) 917–920.
Chen, R. T., Markowitz, L. E., Albrecht, P., Stewart, J. A., Mofenson, L. M., Preblud, S. R., Orenstein, W. A.: Measles anti-body: reevaluation of protective titres. J. Infect. Dis. 162 (1990) 1036–1042.
Samb, B., Aaby, P., Whittle, H. L., Coll Seck, A. M., Rahman, S., Bennett, J., Markowitz, L., Simondom, F., Johnson, C. E., Kumar, M. L., Whitwell, J. K., Staehle, B. O., Rome, L. P., Dinakar, C., Hurni, W., Nalin, D. R.: Serologic status and measles attack rates among vaccinated and unvaccinated children in rural Senegal. Pediatr. Infect. Dis. J. 14 (1995) 203–209.
Skendzel, L. P.: Rubella immunity: defining the level of protective antibody. Am. J. Clin. Pathol. 106 (1996) 170–174.
Hilleman, M. R., Weibel, R. E., Buynak, E. B., Stokes, J., Whitman, J. E.: Live attenuated mumps-virus vaccine. N. Engl. J. Med. 276 (1967) 252–258.
Weibel, R. E., Buynak, E. B., McLean, A. A., Roehm, R. R., Hilleman, M. R.: Persistence of antibody in human subjects for 7 to 10 years following administration of combined live attenuated measles, mumps and rubella virus vaccines (40967). Proc. Soc. Exp. Biol. Med. 165 (1980) 260–263.
Hilleman, M. R., Stokes, J., Buynak, E. B., Weibel, R., Halenda, R., Goldner, H.: Enders’ live measles-virus vaccine with human immune immunoglobulin. Am. J. Dis. Child 103 (1962) 372–379.
Christenson, B., Böttiger, M.: Methods for screening the naturally acquired and vaccine-induced immunity to the measles virus. Biologicals 18 (1990) 207–211.
Neuman, F. W., Weber, J. M., Jessamine, A. G., O'Shaughnessy, M.: Comparison of measles antihemolysin test, enzyme-linked immunosorbent assay, and hemagglutination inhibition test with neutralisation test for determination of immune status. J. Clin. Microbiol. 22 (1985) 296–298.
Skata, H., Hishiyama, M., Sigiura, A.: Enzyme-linked immunosorbent assay compared with neutralization tests for evaluation of live mumps vaccines. J. Clin. Microbiol. 19 (1984) 21–25.
Kimura, M., Kuno-Sakai, H., Yamazaki, S., Yamada, A., Hishiyama, M., Kamiya, H., Ueda, K., Murase, T., Hirayama, M., Oya, A., Nozaki, S., Murata, R.: Adverse events associated with MMR vaccines in Japan. Acta Paediatr. Jpn. 38 (1996) 205–211.
Potin M., Tanaka, J., Chitour K.: Comparison of a novel measles-mumps-rubella (MMR) vaccine with a licensed MMR vaccine. 7th Congress Latinoamericano de Infectologia, 3rd Congreso Venezolano de Infectologia, Bol. Venez. Infectol. 7 (Suppl. 1) (1997) 58.
Briss, P. A., Fehrs, L. J., Parker, R. A., Wright, P. F., Sannalla, E. C., Hutcheson, R. H., Schaffner, W: Sustained transmission of mumps in a highly vaccinated population: assessment of primary vaccine failure and waning vaccine-induced immunity. J. Inf. Dis.169 (1994) 77–82.
Mathias, R. C., Meekison, W. G., Arcand, T. A., Schecter, M. T.: The role of secondary vaccine failures in measles outbreaks. Am. J. Public Health 79 (1989) 475–478.
Johnson, C. E., Kumar, M. L., Whitwell, J. K., Staehle, B. O., Rome, L. P., Dinkar, C., Hurni, W., Nalin, D. R.: Antibody persistence after primary measles-mumps-rubella vaccine and response to second dose given at four to six vs eleven to thirteen years. Pediatr. Inf. Dis. J. 15 (1996) 687–692.
Böttiger, M.: Boosting effect of a second dose of measles vaccine given to 12-year-old children. Scand. J. Infect. Dis. 25 (1993) 239–243.
Schwarzer, S., Reibel, S., Lang, A. B., Struck, M. M., Finkel, B., Gerike, E., Tischer, A., Gassner, M., Glück, R., Stück, B., Cryz, S. J.: Safety and characterization of the immune response engendered by two combined measles, mumps and rubella vaccines. Vaccine 16 (1998) 298–304.
Anderson, R. M., May, R. M.: Immunisation and herd immunity. In:Arnold, E. (ed.): Modern vaccines, a Lancet review. Lancet 335 (1990) 24–33.
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Usonis, V., Bakasenas, V., Chitour, K. et al. Comparative study of reactogenicity and immunogenicity of new and established measles, mumps and rubella vaccines in healthy children. Infection 26, 222–226 (1998). https://doi.org/10.1007/BF02962367
- Aseptic Meningitis
- Seroconversion Rate