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Clinical evaluation of the Makari intradermal test in patients with cancer of the colon and rectum

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Diseases of the Colon & Rectum

Abstract

A clinical study to evaluate the Makari Intradermal Test (MIT) involved 180 patients seen with sympotoms suggestive of malignant disease, 85 of whom were subsequently shown to have carcinoma of the large bowel, and 66 asymptomatic volunteers. The prognostic value of initial and serial studies relative to patient-survival rate and the efficacy of serial studies in detecting disease in long-term follow-up of patients with resected malignant lesions were evaluated. On the basis of this study, the MIT appears to merit further investigation, not as a definitive diagnostic procedure, but as a survey for identifying patients with early malignancy or individuals at high risk to malignant epigenesis.

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References

  1. Baum H. Possible role of mitochondria in oncogenesis (letter). Lancer 1973;2:738–9.

    Article  CAS  Google Scholar 

  2. Bernhard W. Ultrastructure of the cancer cell. In: Lima-DeFaria A, ed. Handbook of molecular cytology, New York. North-Holland Publishing Co, 1969;687.

    Google Scholar 

  3. Racker E. Biochergetics and the problem of tumor growth. Am Sci 1972;60:56–63.

    PubMed  CAS  Google Scholar 

  4. Welch CE. The treatment of polyps of the colon. Surg Gynecol Obstet 1951:93:368–9.

    Google Scholar 

  5. Makari JG. Recent studies in the immunology of cancer. V. Detection of tumors in man by the skin testing of polysaccharide antibody complexes. J Am Geriatr Soc 1960;8:675–88.

    PubMed  CAS  Google Scholar 

  6. Blake KE, Concannon JP, Dalbow MH, Panahandeh A. Diagnostic and prognostic significance of the Makari intradermal test in patients with colon cancer. Excerpta Med Int Congr Series 1979;439:145.

    Google Scholar 

  7. Boisivon A. Clinical investigation with the Makari tumor skin test in France. Trans NY Acad Sci 1973;35:380–6.

    CAS  Google Scholar 

  8. Concannon JP, Blake KE, Brodmerkel GJ Jr, Zemel R, Liebler GA, Nambisan PY. Discussion paper: evaluation of the Makari intradermal test in the diagnosis of cancer. Ann NY Acad Sci 1976;276:97–105.

    Article  PubMed  CAS  Google Scholar 

  9. Concannon JP, Dalbow MH, Eng, CP, Blake KE, Evaluation of the Makari test for the detection of primary and recurrent cancer. In: Nieburgs HE, ed. Prevention and detection of cancer. New York: Marcel Dekker Inc, part II, vol 1 1978;729.

    Google Scholar 

  10. Honda K, Hoshishima K, Kato K, Okazaki T, Higuchi Y, Ikeda M. Studies with the Makari tumor skin test in Japan. Trans NY Acad Sci 1973;35:368–79.

    CAS  Google Scholar 

  11. Makari JG. The intradermal cancer test (ICT). J Am Geriatr Soc 1969;17:755–89.

    PubMed  CAS  Google Scholar 

  12. Tee DE, Studies with the Makari tumor skin test in the United Kingdom. Trans NY Acad Sci 1973;35:387–95.

    CAS  Google Scholar 

  13. Tee DE, Munson KW, Modified Makari skin-test in follow-up of bladder-cancer patients. Lancet 1977;2:480–1.

    Article  PubMed  CAS  Google Scholar 

  14. Concannon JP, Dalbow MH, Liebler GA, Blake KE, Weil CS, Cooper JW. The carcinoembryonic antigen assay in bronchogenic carcinoma. Cancer 1974;34:184–92.

    Article  PubMed  CAS  Google Scholar 

  15. Hansen HJ, Snyder JJ, Miller E, et al. Carcinoembryonic antigen (CEA) assay: a laboratory adjunct in the diagnosis and management of cancer. Hum Pathol 1974;5:139–47.

    Article  PubMed  CAS  Google Scholar 

  16. Staging of cancer of the colon and rectum. In: Manual for staging of cancer—American Joint Committee for Cancer Staging and End Results Reporting. Chicago: American Joint Committee 1987;77.

  17. Cutler SJ, Ederer F. Maximum utilization of the life table method in analyzing survival. J Chron Dis 1958;8:699–712.

    Article  PubMed  CAS  Google Scholar 

  18. Gehan EA. A generalized Wilcoxon test for comparing arbitrarily singly-censored samples. Biometrika 1965;52:203–23.

    PubMed  CAS  Google Scholar 

  19. Bockus H, Tachdjian V, Ferguson LK, Mouhran Y, Chamberlain C. Adenomatous polyp of colon and rectum: Its relations to carcinoma. Gastroenterology 1961;41:225–32.

    Google Scholar 

  20. Dawson IM, Pryse-Davies J. The development of carcinoma of the large intestine in ulcerative colitis. Br J Surg 1959;47:113–28.

    Article  PubMed  CAS  Google Scholar 

  21. Dobbins WO III, Stock M, Ginsberg AL. Early detection and prevention of carcinoma of the colon in patients with ulcerative colitis. Cancer 1977;40:2542–8.

    Article  PubMed  Google Scholar 

  22. Foreman RC. Carcihoid tumors: a report of 38 cases. Ann Surg 1952;136:838–55.

    Article  PubMed  CAS  Google Scholar 

  23. Goldgraber MB, Kirsner JB. Carcinoma of the colon in ulcerative colitis. Cancer 1964;17:657–65.

    Article  PubMed  CAS  Google Scholar 

  24. Goldgraber MB, Kirsner JB: Polyps and carcinoma of the colon. Arch Intern Med 1957;100:669–77.

    CAS  Google Scholar 

  25. Kiefer ED, Eytinge EJ, Johnson AC. Malignant degeneration in chronic ulcerative colitis. Gastroenterology 1951;19:51–7.

    PubMed  CAS  Google Scholar 

  26. Kozuka S. Premalignancy of the mucosal polyp in the large intestine: I. Histologic gradation of the polyp on the basis of epithelial pseudostratification and glandular branching. Dis Colon Rectum 1975;18:483–93.

    Article  PubMed  CAS  Google Scholar 

  27. Kozuka S, Nogaki M, Ozeki T, Masumori S. Premalignancy of the mucosal polyp in the large intestine: II. Estimation of the periods required for malignant transformation of mucosal polyps. Dis Colon Rectum 1975;18:494–500.

    Article  PubMed  CAS  Google Scholar 

  28. Kozuka S, Taki T, Kubota K, Yokoyama Y. Simultaneous transition of multiple polyps into carcinoma in the large intestine. Dis Colon Rectum 1976;19:655–9.

    Article  PubMed  CAS  Google Scholar 

  29. McCollum JK. Large bowel polyps: a clinical assessment. J R Coll Surg Edinb 1976;21:278–84.

    Google Scholar 

  30. MacDougall IP. The cancer risk in ulcerative colitis. Lancet 1964;2:655–8.

    Article  PubMed  CAS  Google Scholar 

  31. Morson BC. Precancerous and early malignant lesions of the large intestine. Br J Surg 1968;55:725–31.

    Article  PubMed  CAS  Google Scholar 

  32. Morson BC. Evolution of cancer of the colon and rectum. Cancer 1974;34:845–9.

    Article  PubMed  Google Scholar 

  33. Morson BC, Genesis of colorectal cancer. Clin Gastroenterol 1976;5:505–25.

    PubMed  CAS  Google Scholar 

  34. Morson BC, Pang LS. Rectal biopsy as an aid to cancer control in ulcerative colitis. Gut 1967;8:423–34.

    Article  PubMed  CAS  Google Scholar 

  35. Muto T, Bussey HJ, Morson BC. The evolution of cancer of the colon and rectum. Cancer 1975;36:2251–70.

    PubMed  CAS  Google Scholar 

  36. Newman RD, Bennett SJ, Pascal RR. Adenocarcinoma of the small intestine arising in Crohn’s disease: demonstration of a tumor-associated antigen in invasive and intraepithelial components. Cancer 1975;36:2016–9.

    PubMed  CAS  Google Scholar 

  37. Papp JP, Pollard HM. Adenocarcinoma occurring in Crohn’s disease of the small intestine. Am J Gastroenterol 1971;56:149–56.

    PubMed  CAS  Google Scholar 

  38. Pearson CM, Fitzgerald PJ. Carcinoid tumors—a re-emphasis of their malignant nature: review of 140 cases. Cancer 1949;2:1005–26.

    Article  PubMed  CAS  Google Scholar 

  39. Rider JA, Kirsner JB, Moeller HC, Palmer WL. Polyps of the colon and rectum: their incidence and relationship to carcinoma. Am J Med 1954;16:555–64.

    Article  PubMed  CAS  Google Scholar 

  40. Rider JA, Kirsner JB, Moeller HC, Palmer WL. Polyps of the colon and rectum: a four-year to nine-year follow-up study of five hundred thirty-seven patients. JAMA 1959;170:633–8.

    CAS  Google Scholar 

  41. Sherlock P, Winawer SJ. The role of early diagnosis in controlling large bowel cancer: an overview. Cancer 1977;40:2609–15.

    Article  PubMed  CAS  Google Scholar 

  42. Spratt JS Jr, Ackerman LV, Mover GA. Relationship of polyps of the colon to colonic cancer. Ann Surg 1958;148:682–98.

    Article  PubMed  Google Scholar 

  43. Thyers GF, Steiger E, Dudrick SJ. Adenocarcinoma of the small intestine and other malignant tumors complicating regional enteritis: case report and review of the literature. Ann Surg 1969;169:510–8.

    Article  Google Scholar 

  44. Warren KW, Colye EB. Carcinoid tumors of the gastrointestinal tract. Am J Surg 1951;82:372–7.

    Article  PubMed  CAS  Google Scholar 

  45. Watson DW. Ulcerative colitis, autoimmune epiphenomena, and colonic cancer. Cancer 1974;34:867–71.

    Article  PubMed  Google Scholar 

  46. Weedon DD, Shorter RG, Duane MI, Ilstrup DM, Huizenga, KA, Taylor WF. Crohn’s disease and cancer. N Engl J Med 1973;289:1099–1103.

    PubMed  CAS  Google Scholar 

  47. White MT, Arya DV, Tewari KK. Biochemical properties of neoplastic cell mitochondria. J Natl Cancer Inst 1974;53:553–9.

    PubMed  CAS  Google Scholar 

  48. Yardley JH, Keren DF. “Precancer” lesions in ulcerative colitis: a retrospective study of rectal biopsy and colectomy specimens. Cancer 1974;34:835–44.

    Article  PubMed  Google Scholar 

  49. Potet F, Sullard J. Polyps of the rectum and colon. Gut 1971;12:468–82.

    Article  PubMed  CAS  Google Scholar 

  50. Benjamin HB, Klamecki BJ, Herzog JV, Hargarten LW. The anotransabdominal approach to polyps of the colon. Surgery 1967;62:411–6.

    Google Scholar 

  51. Everson TC, Allen MJ. Subtotal colectomy with ileosigmoidostomy and fulguration of polyps in retained colon: evaluation as method of treatment of polyposis (adenomatosis) of colon. Arch Surg 1954;69:806–17.

    CAS  Google Scholar 

  52. Enterline HT. Pathology of colonic polyps as it relates to surgical management. Ann Clin Lab Sci 1974;4:145–50.

    PubMed  CAS  Google Scholar 

  53. Lillehei RC, Wangensteen OH. Bowel function after colectomy for cancer, polyps, and diverticulitis. JAMA 1955;159:163–70.

    CAS  Google Scholar 

  54. Swinton NE, Doane WA. The significance and treatment of polyps of the colon and rectum N Engl J Med 1953;249:673–8.

    PubMed  CAS  Google Scholar 

  55. Turell R, Pomeranz AA, Paradny R, Vellecillo LA. Adenomas of the colon and rectum with special emphasis on therapy. Surg Clin North Am 1955 Oct 35:1259–75.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgery, Division of Radiation Oncology, Allegheny General Hospital, 320 East North Avenue, 15212, Pittsburgh, Pennsylvania

    Abolhassan Panahandeh M.D., Karl E. Blake M.D., Milton H. Dalbow M.S., Joseph P. Concannon M.D., Karl Zimmerman M.D. & George J. Brodmerkel M.D.

  2. Division of Gastroenterology, Allegheny General Hospital, 320 East North Avenue, 15212, Pittsburgh, Pennsylvania

    Abolhassan Panahandeh M.D., Karl E. Blake M.D., Milton H. Dalbow M.S., Joseph P. Concannon M.D., Karl Zimmerman M.D. & George J. Brodmerkel M.D.

Authors
  1. Abolhassan Panahandeh M.D.
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  2. Karl E. Blake M.D.
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  3. Milton H. Dalbow M.S.
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  4. Joseph P. Concannon M.D.
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  5. Karl Zimmerman M.D.
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  6. George J. Brodmerkel M.D.
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Additional information

Read in part at the meeting of the American Society of Colon and Rectal Surgeons, San Diego, California, June 11 to 15, 1978.

This investigation was supported in part by Public Health Service Research Grant 5 S015709 and by Grant Q67 from the Health Research and Services Foundation, Pittsburgh, Pennsylvania.

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Panahandeh, A., Blake, K.E., Dalbow, M.H. et al. Clinical evaluation of the Makari intradermal test in patients with cancer of the colon and rectum. Dis Colon Rectum 24, 161–170 (1981). https://doi.org/10.1007/BF02962326

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  • DOI: https://doi.org/10.1007/BF02962326

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