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Interfacial and free energy effects in aqueous amide cosolvents

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Abstract

Data on the solubility ofp-hydroxybenzoate in amide-water cosolvent system and surface tension of the binary amide-water cosolvents are analyzed in terms of the possible mechanism for cosolvency. The results of the study suggest that strong partitioning of the alkylated amides to the ester surface, thus reducing the hydrophobic interface within the system, may account for much of the cosolvency phenomena observed in these systems.

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Literature Cited

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Authors and Affiliations

  1. College of Pharmacy, Busan National University, 607, Busan, Korea

    Chi Ho Lee & Richard E. Lindstrom

  2. School of Pharmacy, The University of Connecticut, 06268, Storrs, CT, U.S.A.

    Chi Ho Lee & Richard E. Lindstrom

Authors
  1. Chi Ho Lee
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  2. Richard E. Lindstrom
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Lee, C.H., Lindstrom, R.E. Interfacial and free energy effects in aqueous amide cosolvents. Arch. Pharm. Res. 2, 85–88 (1979). https://doi.org/10.1007/BF02959034

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  • DOI: https://doi.org/10.1007/BF02959034

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