Summary
The effect of a single oral dose of ammonium chloride on urinary calcium, magnesium and sodium, has been studied.
A significant increase in the urine values of all three cations was observed on the day of the ammonium chloride administration. A significant increase in urine calcium persisted on the next day. A significant positive correlation was observed between urinary calcium and urinary magnesium on the 3 days of the test.
In order that falsely elevated values should not be obtained, twenty-four hour urine calcium estimations should not be carried out for at least 48 hours following an ammonium chloride acid load.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Albright, F., Burnett, C. H., Parsons, W., Reifenstein, E. C., and Roos, A. (1946). Medicine (Baltimore) 25: 399.
Alcock, N., and MacIntyre, I. (1962). Clin. Sci. 22: 185.
Epstein, F. H. (1960). J. Chron. Dis. 11: 255.
Farquharson, R. F., Salter, W. T. and Aub, J. C. (1931). J. Clin. Invest. 10: 251.
Flocks, R. H. (1939). J. Amer. Med. Ass. 113: 1466.
Hodgkinson, A., and Pyrah, L. N. (1958). Brit. J. Surg. 46: 10.
Knapp, E. L. (1947). J. Clin. Invest. 26: 182.
Lassiter, W. E., Gottschalk, C. W., and Mylle, M. (1963). Amer. J. Physiol. 204: 771.
Lemann, J., Litzow, J. R., and Lennon, E. J. (1967). J. Clin. Invest. 46: 1318.
Marsh, W. H., Fingerhut, B., and Kirsch, E. (1957). Amer. J. Clin. Path. 28: 681.
Martin, F. J., and Golovsky, D. (1966). Med. J. Aust. 1: 936.
Martin, H. E., and Jones, R. (1961). Amer. Heart J. 62: 206.
Myers, W. P. L. (1962). Advanc. Intern Med. 11: 163.
Maurice, P. F., and Henneman, P. H. (1964) Medicine (Baltimore). 40: 316.
Parfitt, A. M., Higgins, B. A., Nassim, J. R., Collins, J. A., and Hilb, A. (1964).
Parfitt, A. M. (1969). Clin. Sci. 36: 267. Clin. Sci. 27: 463.
Peacock, M., Hodgkinson, A., and Nordin, B. E. (1967). Brit. Med. J. 3: 469.
Samiy, A. M., Brown, J. L., Globus, D. L., Kessler, R. H., and Thompson, D. D. (1960). Amer. Physiol. 198: 599.
Snedecor, G. W. (1956). In: Statistical Methods. 5th ed. Ames. Iowa, Iowa State College Press. p. 45.
Technicon Instruments Corporation. (1963). Method N20A. New York. Chauncey.
Walser, M., and Robinson, B. H. (1963). In: The transfer of calcium and strontium across biological membrancs. Ed. R. H. Wasserman, New York, Academic Press. p. 307.
Walser, M. (1961). Amer. J. Physiol. 200: 1099.
Wrong, O., and Davies, H. E. (1959). Quart. J. Med. 28: 259.
Author information
Authors and Affiliations
Additional information
This work was supported in part by the Sydney Hospital Research Fund, Sydney Hospital, Sydney, N.S.W., 200, Australia.
Rights and permissions
About this article
Cite this article
Lavan, J.N. The effect of oral ammonium chloride on the urinary excretion of calcium, magnesium and sodium in man. I. J. Med. Sc. 2, 223–227 (1969). https://doi.org/10.1007/BF02955379
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02955379