Abstract
One hundred and fifty-three consecutive cases of HCC and 25 controls from autopsy material were studied by immunohistochemical method in this paper. A review of the histopathology and demonstration of AFP. alpha- 1-antichymotrypsin (AACT), alpha-1-antitrypsin (AAT) and CEA were made.
Among the tumor markers, AACT yielded the highest positive rate, 109 cases (71%) out of 153 HCC. CEA was the next, 95 cases (62%). AFP and AAT gave the same result, 72 cases (47%). AACT, AAT and CEA were not found in the controls. AFP was present in a few hepatocytes in 1 of 25 controls. The results were in keeping with serum tests so far as the highest positive rate being AACT was concerned. Therefore, combined determination of AACT and AFP would seem a better screening method than by that of AFP alone for survey of HCC.
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References
Sawabu N, et al. Serum tumor markers in patients with hepatocellular carcinoma: diagnosis of alpha-fetoprotein-low or negative patients. Gastroenterol Jpn 1985, 20 (3): 209.
Ordones NG, et al. Comparison of alpha-1-antitrypsin and alpha-1-antichymotrypsin in hepatocellular carcinoma: an immunoperoxidase study. Am J Gastroenterol 1984; 79 (12): 959.
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Jing, X., Yu, P. Detection of alpha-1-antichymotrypsin in hepatocellular carcinoma tissue. Chinese Journal of Cancer Research 3, 53–56 (1991). https://doi.org/10.1007/BF02955268
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DOI: https://doi.org/10.1007/BF02955268