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Interactions of histone, ribonuclease and acridine orange in enhancing film sarcoma

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Abstract

ARGININE-RICH histone, ribonuclease and acridine orange were tested in various combinations for their ability to enhance the yield of film sarcoma when applied to segments of cellulose filters implanted in mice for up to 100 weeks. The mixture of all three substances was the most potent. Acridine was effective with either of the others. The enhancing effect of histone was related to its dose. The presence of ribonuclease neutralised the enhancing effect of histone. Tumour on the filter arose most often on plain histone and plain acridine sites and on the area of mixture of acridine with ribonuclease. None arose from plain ribonuclease sites. Substances of cellular origin can independently foment neoplasia, and can inhibit one another’s fomentation while each augments that of a non-cellular carcinogen.

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Authors and Affiliations

  1. Department of Experimental Medicine, University College, Galway

    S. M. Lavelle & M. Maclomhair

Authors
  1. S. M. Lavelle
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  2. M. Maclomhair
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Lavelle, S.M., Maclomhair, M. Interactions of histone, ribonuclease and acridine orange in enhancing film sarcoma. I.J.M.S. 152, 272–275 (1983). https://doi.org/10.1007/BF02954796

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  • DOI: https://doi.org/10.1007/BF02954796

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