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Significance of cea and CA242 in the diagnosis of colorectal carcinoma

  • Wu Jianxiong 
  • Yu Hongtiao 
  • Shao Yongfu 
  • Han Xiaohong 
  • Zhang Yu 
Clinical Observations

Abstract

Carcinoembryonic antigen (CEA) is frequently used in the diagnosis of the colorectal carcinoma. CA242 is a novel unique tumor-associated antigen characterized by higher tumor specificity and sensitivity for colorectal cancer, as compared with other mucin antigens. In this study, preoperative levels of serum CEA and CA242 were measured in 63 cases of colorectal carcinoma. It was disclosed that the positive rate of CA242 was higher than that of CEA, particularly in patients with colon cancer. The combined determination of CEA and CA242 significantly increased the sensitivity and accuracy in the detection of colorectal cancer as compared with the use of CEA alone (P<0.01). In patients with advanced disease the positive rate was markedly elevated, especially in patients with liver metastasis. The results indicate that the combined use of CEA and CA242 assays is an useful adjunct diagnostic measure for colorectal carcinoma, and is helpful in the assessment of the stage of the disease as well as in making treatment plan.

Key words

Colorectal carcinoma Rectal tumor Carcinoembryonic antigen (CEA) Tumor-associated carbohydrate antigen 

References

  1. 1.
    Shuster J, Silverman M, Gold P. Metabolism of human carcinoembryonic antigen in xenogeneic animals. Cancer Res 1973; 33: 65.PubMedGoogle Scholar
  2. 2.
    Johansson c, Nilsson O, Baeckstrom D, et al. Novel epitopes on the antigen:chemical and immunochemical studies. Tumor Biol 1991; 12: 159.CrossRefGoogle Scholar
  3. 3.
    Kuusela P, Haglund C, Rogberts PJ. Comparison of a new tumor marker CA19-9, CA50 and carcinoembryonic antigen (CEA) in digestive tract diseases. Br J Cancer 1991; 63: 636.PubMedGoogle Scholar
  4. 4.
    Haglund C, Lindgren J, roberts PJ, et al. Tissue expression of the tumor associated antigen CA242 in benign and malignant pancreatic lesions. A comparison with CA50 and CA19-9. Br J Cancer 1989; 60: 845.PubMedGoogle Scholar
  5. 5.
    Nilssion O, Johansson C, Glimelius B, et al. Sensitivity and specificity of CA242 in gastrointestinal cancer, a comparison with CEA, CA50 and CA19-9. Br J Cancer 1992; 65: 215.Google Scholar
  6. 7.
    Judith P, Johnson C. Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic diseases. Cancer Metastasis Rev 1991; 10: 11.CrossRefGoogle Scholar
  7. 8.
    Danny Boucher, Denis Cournoyer, Clifford P Stanners, et al. Studies on the control of gene expression of the carcinoembryonic antigen family inhuman tissue. Cancer Res 1989; 49: 847.Google Scholar

Copyright information

© Chinese Journal Of Cancer Research 1996

Authors and Affiliations

  • Wu Jianxiong 
    • 1
  • Yu Hongtiao 
    • 1
  • Shao Yongfu 
    • 1
  • Han Xiaohong 
    • 1
  • Zhang Yu 
    • 1
  1. 1.Department of Abdominal Surgery, Cancer Institute (Hospital)Chinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing

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