Chinese Journal of Cancer Research

, Volume 8, Issue 4, pp 260–262 | Cite as

Morphological and quantitative study on stromal microvasculature of nasopharyngeal precancerous lesions

  • Liu Kela 
  • Yun Jingping 
  • Hou Jinghui 
Clinical Observations


The stromal microvasculature in 27 cases of nasopharyngeal precancerous lesions (NPP) were studied for morphological features and parameter quantitation by computerized image analysis system. FVIIIR:Ag was used as a vascular endothelium marker to show the blood vessels by immunohistochemistry. The microscopic and quantitative results show that most cases (79%) had hyperplastic abnormal blood vessels similar to the stromal neovascularization of nasopharyngeal carcinoma (NPC). These findings suggest that angiogenesis may be a prerequisite to cancerous transformation of nasopharyngeal epithelium, and that cases of NPP with neovascularization have a high tendency to cancerous transformation.

Key words

Nasopharyngeal carcinoma Precancerous lesion Angiogenesis 


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Copyright information

© Chinese Journal Of Cancer Research 1996

Authors and Affiliations

  • Liu Kela 
    • 1
  • Yun Jingping 
    • 1
  • Hou Jinghui 
    • 1
  1. 1.Department of Pathology, Tumor HospitalSun Yet-sen University of Medical SciencesGuangzhou

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