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Chinese Journal of Cancer Research

, Volume 8, Issue 4, pp 249–252 | Cite as

Pathological studies on the anti-invasive character by recombinant human interleukin-6 gene-transfected mouse leukemia cells

  • Ge Linfu 
  • Cao Xuetao 
  • Ma Dalie 
  • Li Jinsong 
  • Zhang Fuzhou 
  • Yu Yizhi 
  • Ye Tianxing 
Basic Investigations

Abstract

Mouse FBL-3 erythroleukemia cells were transfected with recombinant human interleukin-6 (rhIL-6) gene and a clone secreting IL-6 was selected (i.e., FBL-3-IL-6+). The cell clone secreting IL-6 was inoculated into C57BL/6 mouse. The growth of tumors was observed and histologic analyses of the tumorsin situ, liver, spleen and bone marrow were performed after inoculation. The mice inoculated with wild-type FBL-3 erythroleukemia cells were used as the control. The results showed that the later the tumor occurrence, the slower the tumor development, the lower the pathological changes degree and the longer the survival time in experimental group compared to that of the control. The results demonstrated that the inoculation of the FBL-3 cell clone secreting IL-6 can inhibit the invasion of leukemia cells, suggesting that the FBL-3-IL-6+ cells can be used as a vaccine to treat leukemia.

Key words

Leukemia Experimental interleujin-6 gene transfer Invasion of leukemia cells 

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Copyright information

© Chinese Journal Of Cancer Research 1996

Authors and Affiliations

  • Ge Linfu 
    • 1
  • Cao Xuetao 
    • 1
    • 2
  • Ma Dalie 
    • 1
    • 2
  • Li Jinsong 
    • 1
  • Zhang Fuzhou 
    • 1
  • Yu Yizhi 
    • 1
    • 2
  • Ye Tianxing 
    • 2
  1. 1.General Hospital of Jinan Command, PLAJinan
  2. 2.Second Military Medical UniversityShanghai

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