Summary
HEART rate, blood pressure, and electrocardiographic changes were measured in 11 patients receiving 150 mg ranitidine twice daily. Values were compared with those obtained during antacid treatment. Each patient was subjected to an exercise stress test while on both treatment regimes. All electrocardiograms were allocated a Minnesota Code and read blind by a cardiologist. Comparative values were available for 6 of the patients. The mean heart rate (±S.D.) for ranitidine was 115/min ± 11. The mean systolic pressure (±S.D.) for ranitidine 160 mmHg ±14, and for antacid 160 mmHg ±10, and diastolic pressure 102 mmHg ±11 and 104 mmHg ±12 respectively. The mean PR interval in m.secs (±S.D.) for ranitidine was 131±11 and for antacid 133 ±12. The mean QTc (±S.D.) interval in m.secs for ranitidine was 310±18 and for antacid 305±0.8. In all tracings which were coded the QRS duration was fixed at 8 m.secs. The results indicate that oral ranitidine (150 mg twice daily) did not effect heart rate, systolic or diastolic pressure during dynamic exercise in 6 patients from whom comparative values were available. In all 11 patients no electrocardiographic abnormalities occurred.
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Habba, S.F., Fletcher, E. & Doyle, J.S. The response of heart rate and blood pressure and electrocardiographic changes induced by exercise in patients on oral ranitidine. Ir J Med Sci 152, 238–241 (1983). https://doi.org/10.1007/BF02954723
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DOI: https://doi.org/10.1007/BF02954723