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Long-term studies with the new potassium-sparing diuretic, amiloride (‘MK-870’)

  • Published:
Irish Journal of Medical Science (1968-1970)

Summary and Conclusions

  1. (1)

    Short term studies in five subjects show that amiloride is a potassiumsparing natriuretic agent alone and with thiazide diuretic and ethacrynic acid even when the dose is 5 mg.

  2. (2)

    There was no loss of potassium-sparing effect in four patients receiving the drug continuously for a period of fifteen months or more.

  3. (3)

    Hyperkalaemia did not occur but this is a potential hazard and so regular estimation of the serum potassium is necessary, though this does not give accurate information of the total body potassium. Also, potassium supplements should not be used with amiloride.

  4. (4)

    No serious side effects or toxic reactions were found in this study or by other workers.

  5. (5)

    Amiloride is unlikely to prevent diuretic-induced hyperuricaemia.

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Authors and Affiliations

  1. Department of Medicine, University College, Dublin

    Andrew G. A. Heffernan M.D., M.Sc. (Lecturer in Medicine), Timothy B. Counihan M.D., M.R.C.P. (Professor of Medicine) & Michael Byrne

  2. Mater Misericordiae Hospital, Dublin

    Andrew G. A. Heffernan M.D., M.Sc. (Lecturer in Medicine), Timothy B. Counihan M.D., M.R.C.P. (Professor of Medicine) & Michael Byrne

Authors
  1. Andrew G. A. Heffernan M.D., M.Sc.
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  2. Timothy B. Counihan M.D., M.R.C.P.
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  3. Michael Byrne
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Heffernan, A.G.A., Counihan, T.B. & Byrne, M. Long-term studies with the new potassium-sparing diuretic, amiloride (‘MK-870’). I. J. Med. Sc. 2, 3–16 (1969). https://doi.org/10.1007/BF02954667

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