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The diuresis problem

  • Published:
Irish Journal of Medical Science (1926-1967)

Summary

Physiological, pharmacological, and clinico-pathological causes of diuresis are examined with a view to discovering some common explanation of their actions.

Certain substances, sulphates, desoxycorticosterone, urea, which cause diuresis raise the chloride threshold; others, mercury, purins, causing diuresis lower the threshold.

The threshold is defined as the plasma concentration (CpNaCl) above which chloride is concentrated in the urine at all rates of urine flow.

The hypothesis is developed that diuresis occurs when CpNaCl is more than a few millimols distant from the threshold value.

A wide range of experimental and clinical data may be explained on this basis.

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Authors
  1. T. W. T. Dillon
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Dillon, T.W.T. The diuresis problem. Ir J Med Sci 18, 534–547 (1943). https://doi.org/10.1007/BF02954643

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  • DOI: https://doi.org/10.1007/BF02954643

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