Summary
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1.
Two cases are described in which acute myeloblastic leukaemia was preceded by a pre-leukaemic phase of five and a half and ten years respectively during which there was no haematological evidence of leukaemia.
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2.
In the second case a remission of seven and a half years occurred during the pre-leukaemic phase.
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3.
Immediately prior to the development of the leukaemia in the second case ring sideroblasts were detected in the bone marrow and a raised level of foetal haemoglobin in the peripheral blood.
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4.
In both cases the leukaemic phase progressed rapidly to a fatal termination.
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Hunter, J., Nelson, M.G. & Otridge, B.W. The pre-leukaemic state. Ir. J. Med. Sc. 42, 31–37 (1967). https://doi.org/10.1007/BF02952000
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DOI: https://doi.org/10.1007/BF02952000