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The effect of prolonged achromycin treatment on the nasal and faecal carriage of Staph. pyogenes

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Irish Journal of Medical Science (1926-1967)

Summary

The presence ofStaph. pyogenes in the nasal and intestinal flora of children under prolonged Achromycin treatment has been investigated. The administration of Achromycin in a dosage of 250 mgm. daily has been found to select strongly for resistant strains; most of the Achromycin-resistant organisms selected were in addition resistant to penicillin or to penicillin and streptomycin. Achromycin treatment also appeared to increase the overall parasitism of the intestinal tract byStaph. pyogenes: no increase in nasal parasitism byStaph. pyogenes was observed.

In general our results indicate the importance of the respiratory and intestinal tracts, and particularly the latter, as foci from which, in patients under antibiotic treatment, antibiotic-resistant strains ofStaph. pyogenes may be disseminated.

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References

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Authors and Affiliations

  1. Department of Bacteriology, Trinity College, Dublin

    F. S. Stewart M.D., F.R.C.P.I. & Ruth Crennell B.A.

  2. National Children’s Hospital, Dublin

    E. E. Doyle M.R.C.P.I., D.P.H., D.C.H.

Authors
  1. F. S. Stewart M.D., F.R.C.P.I.
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  2. Ruth Crennell B.A.
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  3. E. E. Doyle M.R.C.P.I., D.P.H., D.C.H.
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Stewart, F.S., Crennell, R. & Doyle, E.E. The effect of prolonged achromycin treatment on the nasal and faecal carriage of Staph. pyogenes. Ir J Med Sci 33, 142–145 (1958). https://doi.org/10.1007/BF02951254

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  • DOI: https://doi.org/10.1007/BF02951254

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