Experimental study on effect of folium ginkgo biloba in treating pulmonary interstitial fibrosis in rats

Abstract

Objective: To evaluate the therapeutic effect and mechanism of folium Ginkgo biloba (FGB) in treating pulmonary interstitial fibrosis (PIF) induced by bleomycin in rats.Methods: PIF models of bleomycin-A₅-induced pulmonary fibrosis were established in rats, they were treated by Bailuda, a preparation of FGB, and the pathological changes, collagen protein level, nuclear factor kB(NF-kB) activity, transforming growth factor β (TGF-β) mRNA expression and protein level of the lung tissue were measured.Results: In the Bailuda treated group after treatment, amelioration of the pulmonary alveolitis and fibrosis were shown in pathological section (P < 0.05) and collagen protein content was lesser (P<0.01) as compared with those in the model control group. After 1 week of Bailuda treatment, the NF-kB activity of pulmonary alveola macrophage lowered by 47. 3 %, and levels of TGF-β mRNA expression and protein were all decreased (P < 0.05).Conclusions: Bailuda has definite effect in treating PIF. The mechanism may be through inhibiting the activity of NF-kB, decreasing TGF-β mRNA expression and protein, so as to ameliorate the inflammation and fibrosis.