Abstract
Objective: To observe the behavioral and biochemical effects of a traditional Chinese medicine Huanshao Dan (HSD) on learning and memory deficits in transient cerebral ischemia model in mice.Methods: Step-through experiments, receptor binding test and choline acetyltransferase (ChAT) activities determination were performed.Results: Mice undertaken transient ischemia commited much more mistakes in step-through experiments and showed relatively higher3 H-MK801 binding in cerebral cortex and hippocampus than in sham operated animals. HSD decoction was most effective in reducing these mistakes in mice. At the same time, and3 H-MK801 binding of cerebral cortex and hippocampus tissues were also significantly decreased, while ChAT activities in the same tissues were increased.Conclusion: HSD might antagonize ischemic injury of brain through inhibition of glutamate N-methyl-D-Aspartic acid receptor overactivity.
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ΔThis program was supported by National Nature Science Foundation of China (No.39421012)
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Liu, N., Zuo, P., Liu, F. et al. Study on mechanism of huanshao dan
in brain protectionΔin brain protectionΔ.
CJIM 6, 200–203 (2000). https://doi.org/10.1007/BF02950928
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DOI: https://doi.org/10.1007/BF02950928