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The immunologic and immunotherapeutic sequelae of intraperitoneal BCG

I: The local nature of immunostimulation and the effects of delayed-type hypersensitivity

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Summary

BCG administered intraperitoneally (IP) was shown to have an immunoprophylactic effect against an ascites tumour. The dosage used was shown to have no immunosuppressive effects, as measured by subcutaneous tumour growth and delayed type hypersensitivity (DTH). In C57BL mice BCG was found to enhance DTH, in contrast with previous immunogenetic studies. The relationship between previously reported BCG-induced immunosuppression and immunotherapy is discussed.

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Authors and Affiliations

  1. Department of Pathology, University College, Dublin

    W. R. Roche & H. McLaughlin

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  1. W. R. Roche
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  2. H. McLaughlin
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Roche, W.R., McLaughlin, H. The immunologic and immunotherapeutic sequelae of intraperitoneal BCG. I.J.M.S. 152, 303–306 (1983). https://doi.org/10.1007/BF02945302

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  • DOI: https://doi.org/10.1007/BF02945302

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