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Mycotoxin Research

, Volume 15, Issue 2, pp 91–95 | Cite as

Mycotoxicological control on raw material and tablets of cascara sagrada (Rhamnus purshiana)

  • Rizzo I
  • Varsavsky E
  • Vedoya G
  • Haidukowski M
  • Frade H
  • Chiale C
Article

Abstract

Among phytotherapic medicines, tablets of cascara sagrada (Rhamnus purshiana) dried bark, usually used as laxative, are commercially widespread in our market. Taking into account natural origin and/or inappropriate procedures that may allow the occurrence of toxinogenic Aspergillus flavus group, a study on susceptibility to aflatoxin contamination and natural aflatoxin incidence was performed by TLC and HPLC methods. This survey allows one to conclude that bark of Cascara Sagrada is a good substrate for the growth of A. parasiticus NRRL 2999 and for aflatoxins production. Natural anatoxins presence was detected on 2 from 9 raw material samples. One of them (irradiated sample) had only aflatoxin B1 (10 μg/kg) and the other (pasteurized) was positive for aflatoxin B1 (19 μg/kg); G1 (6 μg/kg) and B2 (1.46 μg/kg). Only one from 10 lots of tablets analyzed was positive for aflatoxin B1 (5.42 μg/kg) and B2 (0.32 μg/kg).Therefore, adequate quality control including an aflatoxins assay must be performed to guarantee the harmlessness of natural drugs.

Keywords

Aflatoxin Aflatoxin Production Mycotoxin Research Aflatoxin Contamination Immunoaffinity Column 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Society of Mycotoxin Research and Springer 1999

Authors and Affiliations

  • Rizzo I
    • 1
  • Varsavsky E
    • 1
  • Vedoya G
    • 1
  • Haidukowski M
    • 1
  • Frade H
    • 1
  • Chiale C
    • 1
  1. 1.INSTITUTO NACIONAL DE MEDICAMENTOSBuenos AiresArgentina

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