Skip to main content
SpringerLink
Log in

Spectrometric studies on stability of tenuazonic acid (TeA) solution in organic solvents

  • Published:
Mycotoxin Research Aims and scope Submit manuscript

Abstract

The stability of tenuazonic acid solution at different temperatures and storage times was studied using methanol, methanol-water (8:2 v/v), benzene and benzene-acetonitrile (98:2 v/v) as solvents. Solutions were analysed by a spectrometric method TeA U.V.-spectrum was recorded. Results indicated that the optimum temperature for long-time storage period of tenuazonic acid solution in any solvent assayed is -20°C. Benzene and benzene-acetonitrile (98:2 v/v) could be advised to make tenuazonic acid solution which will be stored less than 2 months at 4°C. Methanol and methanolwater (8:2 v/v) are not recommended because a low stability of TeA solution in this solvents.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dalcero A, Chulze S, Etcheverry M, Farnochi C, Varsavsky E ((1989) Aflatoxins in sunflower seeds: influence ofAlternaria alternata on aflatoxin production byAspergillus parasiticus. Mycopath 108: 31–35.

    Article  CAS  Google Scholar 

  2. Torres A, Chulze S, Varsavsky E, Rodriguez M ((1993)Alternaria metabolites in sunflower seeds. Incidence and effect of pesticides in their production. Mycopath 121: 17–20.

    Article  CAS  Google Scholar 

  3. Chulze S, Torres A, Dalcero A, Etcheverry M, Ramirez M, Farnochi C (1995)Alternaria mycotoxins in sunflower seeds: incidence and distribution of the toxins in oil and meal. Food Protection 58: 1133–1135.

    CAS  Google Scholar 

  4. Stinson E, Osman D, Heisler E, Siciliano J, Billis D (1981) Mycotoxins production in whole tomatoes, apples, oranges, and lemons. J Agric Food Chem, 29: 790–792.

    Article  PubMed  CAS  Google Scholar 

  5. Logrieco A, Bottalico A, Visconti A, Vurro M (1988) Natural occurrence ofAlternaria mycotoxins in some plant products. Microb Alim Nutr 6: 13–17.

    Google Scholar 

  6. Robiglio AL, Lopez SE (1995) Mycotoxin production byAlternaria alternata strains isolated from red delicious apples in Argentina. International J Food Microbiol 24: 413–417.

    Article  CAS  Google Scholar 

  7. Visconti A, Sibila A (1994) Alternaria Toxins. In: Miller JD, Trenholm HL (Eds.) Mycotoxins in Grain Compounds Other than Aflatoxins, Eagan Press, St. Paul, Minnesota U.S.A., pp. 315–335.

    Google Scholar 

  8. Miller FA, Rightsel WA, Sloan BJ, Ehrlich J, French JC, Bartz QR (1963) Antiviral activity of tenuazonic acid. Nature 200: 1338–1339.

    Article  PubMed  CAS  Google Scholar 

  9. Gitterman CO (1965) Antitumor, cytotoxic, and antibacterial activities of tenuazonic acid and cogeneric tetramic acid. J Med Chem 8: 483–486.

    Article  PubMed  CAS  Google Scholar 

  10. Smith ER, Fredrickson TN, Hadidian Z (1968) Toxic effects of the sodium and the N,N’-dibenzylethylenediamine salts of tenuazonic acid (NSC-525816 and NSC-82260). Cane Chemotherapy Rep 52: 579–585.

    CAS  Google Scholar 

  11. Watson DH (1984) An assessment of food contaminants by toxic products of Alternaria. J Food Protection 47: 485–488.

    CAS  Google Scholar 

  12. Shigeura HT, Gordon CN (1963) The biological activity of tenuazonic acid. Biochem 2: 1132–1137.

    Article  CAS  Google Scholar 

  13. Carrasco L, Vasquez D (1973) Differences in eukaryotic ribosome detected by selective action of an antibiotic. Biochem Biophys Acta 319: 209–215.

    PubMed  CAS  Google Scholar 

  14. Schade JE, King AD (1984) Analysis of the mayor Alternaria toxins. J Food Protection 47: 978–995.

    CAS  Google Scholar 

  15. Ciegler A, Lillehoj GB (1968) Mycotoxins. Adv Appl Microbiol 10: 155–219.

    Article  PubMed  CAS  Google Scholar 

  16. Stoloff L, Trager W (1965) Recommended decontamination procedures for aflatoxin. J Assoc Off Anal Chem 48: 681–682.

    CAS  Google Scholar 

  17. Scott PM, Kanhere SR (1980) Liquid chromatographic determination of tenuazonic acid in tomato paste. J Assoc Off Anal Chem 63: 612–621.

    PubMed  CAS  Google Scholar 

  18. Montemurro N, Visconti A (1992) Alternaria metabolites, chemical and biological data. In: Chelkowsky J, Visconti A (Eds.) Alternaria, Biology, Plant Diseases and Metabolites, Elsevier, Amsterdam, pp.514–515.

    Google Scholar 

  19. Garcia ME, Blanco JL, Suarez G (1994) Aflatoxin B1 and G, solubility in standard solution and stability during cold storage. Myco Res 10: 97–100.

    CAS  Google Scholar 

  20. Beaver RW (1990) Degradation of aflatoxins in common HPLC solvents. J High Res Chrom 13: 833–835.

    Article  CAS  Google Scholar 

  21. Wei R, Chu FS (1986) Instability of some trichotecenes in methanol. J Assoc Off Anal Chem 69: 902–903.

    PubMed  CAS  Google Scholar 

  22. Trusal LR (1985) Stability of T-2 mycotoxin in aqueous media. Appl Environm Microbiol 50: 1311–1312.

    CAS  Google Scholar 

  23. Visconti A, Doko MB, Bottalico C, Schurer B, Boenke A (1994) Stability of fumonisins (FBI and FB2) in solution. Food Add Contam 11:427–431.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Microbiología e Inmunología. Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Ruta 8 km 601 (5800) Río Cuarto, CÓrdoba, Argentinia

    Combina M, Dalcero AM & Torres A

Authors
  1. Combina M
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dalcero AM
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Torres A
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Torres A.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Combina, M., Dalcero, A. & Torres, A. Spectrometric studies on stability of tenuazonic acid (TeA) solution in organic solvents. Mycotox Res 14, 54–59 (1998). https://doi.org/10.1007/BF02945094

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02945094

Keywords

Search

Navigation