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Carbimazole induced agranulocytosis: Rescue with human recombinant Granulocyte Colony Stimulating factor

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Summary

We report on a 25 yr old woman with primary autoimmune hyperthyroidism who was treated with carbimazole. Forty-three days later she developed agranulocytosis (64 × 106/l). With 4 days treatment with recombinant human Granulocyte Colony Stimulating factor the granulocyte count rose to normal — 4,350 cells X 106/l. This is considerably faster than the rate of spontaneous recovery which usually takes one to 2 weeks.

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Authors and Affiliations

  1. Department of Medicine, Limerick Regional General Hospital, Ireland

    J. A. O’Hare & T. Azher

  2. University College Cork, Ireland

    J. A. O’Hare & T. Azher

Authors
  1. J. A. O’Hare
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  2. T. Azher
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O’Hare, J.A., Azher, T. Carbimazole induced agranulocytosis: Rescue with human recombinant Granulocyte Colony Stimulating factor. I.J.M.S. 166, 239–240 (1997). https://doi.org/10.1007/BF02944242

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  • DOI: https://doi.org/10.1007/BF02944242

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