Summary
In acute experiments Triamterene caused moderate diuresis and natriuresis, the onset of action being apparent at the end of 1 hour and lasting for 6 hours. Urinary potassium content was diminished. Urinary chloride and bicarbonate were increased. Urinary pH rose.
In oedematous patients, moderate diuresis and natriuresis with diminution of urinary potassium content were also observed. The diuresis was less than that induced by chlorothiazide. The addition of Triamterene to chlorothiazide accentuated existing diuresis. It also reduced the urinary potassium loss resulting from chlorothiazide. The combination of Triamterene with spironolactone produced satisfactory diuresis.
The greatest diuresis followed the administration of all 3 drugs simultancously.
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Bourke, E., Counihan, T.B., Farrell, I. et al. Clinical trial of the diuretic triamterene. Ir. J. Med. Sc. 40, 57–65 (1965). https://doi.org/10.1007/BF02943824
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DOI: https://doi.org/10.1007/BF02943824