Summary
Helicobacter pylori infection has been implicated with the development of gastric carcinoma and lymphoma. We studied the long-term effects ofH. pylori infection on gastric mucosa. Ten patients withHelicobacter pylori infection underwent repeat endoscopy and antral biopsies 8 years later. Gastric mucosal features (polymorphs, monocytes, intestinal metaplasia, atrophy and lymphoid aggregates) were graded from mild to severe (0 to 3) based on the Sydney system of gastritis classification.
At repeat biopsy, 1 patient was negative forH. pylori after eradication therapy. Two patients (20 per cent) had spontaneous disappearance ofH. pylori. One of these had intestinal metaplasia which progressed to low grade dysplasia. Polymorphs decreased with eradication ofH. pylori (P< 0.05). Lymphoid aggregates increased with continuedH. pylori infection but decreased with eradication ofH. pylori (P< 0.05). Monocytes, intestinal metaplasia and atrophy remained unchanged.
PersistentH. pylori infection appears to increase lymphoid aggregates and may promote its evolution into gastric lymphoma while eradication ofH. pylori may result in a reduction of polymorphs and lymphoid aggregates.
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Tham, T.C.K., Sloan, J.M. & Collins, J.S.A. Long-term semi-quantitative follow-up ofHelicobacter pylori associated gastritis. I.J.M.S. 166, 132–134 (1997). https://doi.org/10.1007/BF02943589
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DOI: https://doi.org/10.1007/BF02943589