The influence of finger pressing manipulation on cAMP and cGMP in the cerebrospinal fluid of prolapsed intervertebral disc

Abstract

This study used the radioimmunoassay method to observe 11 cases of prolapsed intervertebral disc and to detect the change of cAMP and cGMP in the cerebrospinal fluid before and after finger pressing manipulation in acupuncture point Weizhong (UB 40) and Chengshan (UB 57) in order to discuss the mechanism of analgesia of finger pressing manipulation. The results show the pain was relieved after finger pressing manipulation. cGMP of the cerebrospinal fluid increased from 0.51±0.19 to 0.63±0.13 pm/ml, in average 32% higher than before the treatment (P<0.05). Since cAMP/cGMP decreased from 30.52±26.42 to 23.20±16.91. this shows the analgesic mechanism of finger pressing manipulation might be due to the fact that the therapy excited the selectively endogenous analgesic system, caused the increased release of endorphin, and was accompanied by regulation of cAMP and cGMP.