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Helicobacter pylori and gastro-oesophageal reflux disease — A prospective study

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Abstract

In a prospective evaluation of the relationship between Helicobacter pylori infection and gastrooesophageal reflux disease (GORD), 93 consecutive patients (47 female: 46 male: mean age, 46 years: range 13-93) with symptoms and endoscopic evidence of GORD were studied. A total of 50 patients (54%) wereH. pylori-positive on gastric antral biopsies. No significant correlation was detected betweenH. pylori status and grade of oesophagitis. The prevalence ofH. pylori infection showed a gradual increase with age. Of 64 patients with a hiatal hernia, 28 (44%) had histological evidence of H. pylori infection of the hernia mucosa; 27 of these patients (96%) had associatedH. pylori in the gastric antrum. Of the 36 patients whose hiatal hernia wasH. pylori-negative, only 6 (17%) had antralH. pylori (P<0.001). Of the 8 patients found to have Barrett’s oesophagus, only 1 hadH. pylori detected on the Barrett’s mucosa. Our results do not support the presence of a significant association betweenH. pylori infection and GORD.

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Authors and Affiliations

  1. Department of Medicine, General Hospital, Tullamore, Co., Offaly, Ireland

    H. J. O’Connor

  2. Departments of Pathology, General Hospital, Tullamore, Co., Offaly, Ireland

    K. Cunnane

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  1. H. J. O’Connor
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  2. K. Cunnane
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O’Connor, H.J., Cunnane, K. Helicobacter pylori and gastro-oesophageal reflux disease — A prospective study. I.J.M.S. 163, 369–373 (1994). https://doi.org/10.1007/BF02942830

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