Abstract
The natural killer cell activity of peripheral blood mononuclear cells from 28 patients with systemic lupus erythematosus was measured using enzyme-release assay. The patients exhibited obviously decreased natural killer cell activity compared with the healthy subjects in the control group. The natural killer cell dysfunction was related to steroidal therapy, but not to three auto-antibodies. The release of a soluble natural killer cytotoxic factor by the peripheral blood mononuclear cells was tested by cytotoxicity assay induced in K562 cells. This release was significantly lower in the test group than in the control group. Pre-incubation of peripheral blood mononuclear cells withAstragalus membranaceus andTripterygium hypoglaucum considerably enhanced natural killer cytotoxicity by stimulating the release of soluble cytotoxic factors.
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References
Tan E, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271.
Barada F, et al. Antibodies to Sm patients with SLE: Correlation of Sm antibody titers with disease activity and other laboratory parameters. Arthritis Rheum 1981;24:1236.
Korzeuiewski C, et al. An enzyme-release assay for natural cytotoxicity. J Immunol Meth 1983;64:313.
Sibbitt E, et al. Impaired release of a soluble natural killer cytotoxic factor in SLE. Arthritis Rheum 1984;27:1095.
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Zhao, Xz., Liu, Fr. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus. CJIM 1, 111–113 (1995). https://doi.org/10.1007/BF02942761
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DOI: https://doi.org/10.1007/BF02942761