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Rigorous model for spherical cell-support aggregate

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Abstract

The activity of immobilized cell-support particle aggregates is influenced by physical and biochemical elements, mass transfer, and physiology. Accordingly, the mathematical model discussed in this study is capable of predicting the steady state and transient concentration profiles of the cell mass and substrate, plus the effects of the substrate and product inhibition in an immobilized cell-support aggregate. The overall mathematical model is comprised of material balance equations for the cell mass, major carbon source, dissolved oxygen, and non-biomass products in a bulk suspension along with a single particle model. A smaller bead size and higher substrate concentration at the surface of the particle, resulted in a higher supply of the substrate into the aggregate and consequently a higher biocatalyst activity.

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Authors and Affiliations

  1. Department of Environmental Science and Engineering, Kwangju Institute of Science and Technology, 500-712, Kwangju, Korea

    Seung-Hyeon Moon & Ki Beom Lee

  2. Department of Chemical and Environmental Engineering, Illinois Institute of Technology, 60616-3793, Chicago, IL, USA

    Satish J. Paruekar

Authors
  1. Seung-Hyeon Moon
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  2. Ki Beom Lee
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  3. Satish J. Paruekar
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Correspondence to Seung-Hyeon Moon.

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Moon, SH., Lee, K.B. & Paruekar, S.J. Rigorous model for spherical cell-support aggregate. Biotechnol. Bioprocess Eng. 6, 42–50 (2001). https://doi.org/10.1007/BF02942249

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  • DOI: https://doi.org/10.1007/BF02942249

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