Summary
In a bid to minimise dosage and possible side-effects when relieving post episiotomy pain, the NSAID Indomethacin was studied in combination with a systemic haemostat Ethamsylate which has been shown to selectively inhibit some prostaglandins. Comparative groups also took Indomethacin alone and placebo in a double blind non-crossover comparison.
Efficacy was judged in terms of side-effects and assessments of pain intensity, pain relief and global assessment of pain. There was some evidence of a beneficial interaction between Indomethacin and Ethamsylate when adjustments were made for the patient’s age and initial pain score. Side-effects were most common in the combination therapy group.
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Harrison, R.F., Devitt, M. Indomethacin and ethamsylate alone and in combination for the relief of post episiotomy pain. I.J.M.S. 161, 493–497 (1992). https://doi.org/10.1007/BF02942121
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DOI: https://doi.org/10.1007/BF02942121