Skip to main content
SpringerLink
Log in

Failure of cord serum cholesterol and betalipoprotein as screening tests for familial hyperlipoproteinaemia

  • Published:
Irish Journal of Medical Science Aims and scope Submit manuscript

Summary

Cord serum lipids including immunoreactive beta lipoprotein were measured in a group of 2044 neonates. Infants with values over the 95th percentile were followed up over a 3 year period to evaluate the usefulness of cord blood testing as a screen for subsequent hyperlipidaemia. Eight children were identified as persistently hyperlipidaemic; a further 96 infants proved to be “false-positives”. The two groups could not be distinguished by retrospective examination of the cord figures. This study confirms that cord serum total cholesterol is not of value as a population screening test and indicates that immunochemically measured beta-lipoprotein is no better.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Allain, C. C., Poon, H., Chan, S. G., Richmond, W. and Fu, P. 1974. Enzymatic determination of serum cholesterol. Clin. Chem. 20, 470.

    PubMed  CAS  Google Scholar 

  • Andersen, G. E. and Friis-Hansen, B. 1976. Neonatal diagnosis of familial type II hyperlipoproteinemia. Pediatrics 57, 214.

    PubMed  CAS  Google Scholar 

  • Brewster, J. G., Waite, D. J. and Hudson, G. A., 1982. Quantitation of beta-lipoprotein in cord serum by rate nephelometric immunoassay: a potential screening test for familial hypercholesterolemia. Clin. Chem. 28, 1192.

    PubMed  CAS  Google Scholar 

  • Bucolo, G. and David, H. 1973. Quantitative determination of serum triglycerides by the use of enzymes. Clin. Chem. 19, 476.

    PubMed  CAS  Google Scholar 

  • Conover, W. J. 1971. Practical nonparametric statistics. New York: Wiley, 223–237.

    Google Scholar 

  • Darmady, J. M., Fosbrooke, A, S. and Lloyd, J. K. 1974. Prospective study of serum cholesterol levels drsuring first year of life. Brit. Med. J. ii, 685.

    Google Scholar 

  • Fredrickson, D. S., Goldstein, J. H. and Brown, M. S. 1978. The Familial Hyperlipoproteinemias. In: The Metabolic Basis of Inherited Disease. Eds. J. B. Stanbury, J. B. Wyngaarden and J. S. Fredrickson. 4th ed. New York: McGraw-Hill. 604.

  • Glueck, C. J., Heckman, J., Schoenfeld, M., Steiner, P. and Pearce, W. 1971. Neonatal Familial Type II Hyperlipoproteinemia: Cord Blood Cholesterol in 1800 births. Metabolism 20, 597.

    Article  PubMed  CAS  Google Scholar 

  • Glueck, C. J. and Tsang, R. C. 1972. Pediatric familial type II hyperlipoproteinemia: effects of diet on plasma cholesterol in the first year of life. Am. J. Clin. Nutr. 25, 224.

    PubMed  CAS  Google Scholar 

  • Kannel, W. B. and Dawber, T. R. 1972. Atherosclerosis as a pediatric problem. J. Pediatr. 544.

  • Kwiterovich, P. O. Jr., Levy, R. I. and Fredrickson, D. S. 1973. Neonatal diagnosis of familial type II hyperlipoproteinaemia. Lancet i, 118.

    Article  Google Scholar 

  • Ose, H. 1975. LDL and total cholesterol in cordblood screening for familial hypercholesterolaemia. Lancet ii, 615.

    Article  Google Scholar 

  • Ritchie, R. F. 1978. Automated immunochemical analysis of human low density lipoproteins. In: Automated Immunoanalysis, part 1. Ed. R. F. Ritchie. New York. Dekker. 267.

  • Vladutiu, G. D., Glueck, C. J., Schultz, M. T. and Guthrie, R. 1980. Beta-lipoprotein quantitation in cord blood spotted on filter paper: a screening test. Clin. Chem. 26 L 1285.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Children’s Research Centre, Our Lady’s Hospital for Sick Children, Crumlin, Dublin 12

    D. Kenny, O. C. Ward, B. Mulhern & A. A. Rashied

Authors
  1. D. Kenny
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. C. Ward
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Mulhern
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. A. Rashied
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kenny, D., Ward, O.C., Mulhern, B. et al. Failure of cord serum cholesterol and betalipoprotein as screening tests for familial hyperlipoproteinaemia. I.J.M.S. 153, 100–105 (1984). https://doi.org/10.1007/BF02942001

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02942001

Keywords

Search

Navigation