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Efficacy of ganglioside treatment in reducing functional alterations induced by vincristine in rabbit peripheral nerves

Cancer Chemotherapy and Pharmacology volume 26, Article number: 31 (1990) Cite this article

Summary

Vincristine (VCR) administration to rabbits resulted in severe electrophysiologic alterations of peripheral nerves. Sciatic nerve conduction velocity, compound action potential (CAP) amplitude, and area under the CAP waveform were all reduced in a dose-dependent fashion. In addition, the pattern of conduction velocity of both motor and sensory fibers was altered and shifted toward slow conduction classes. Simultaneous treatment with gangliosides limited significantly the changes in electrophysiologic parameters induced by VCR. It is suggested that gangliosides be given in the clinical setting as protection for the peripheral nerves against the side effects of antiblastic therapy.

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Affiliations

  1. Department of Peripheral Nervous System Research, Fidia Research Laboratories, Via Ponte della Fabbrica, 3/A, I-35031, Abano Terme (PD), Italy

    Franco Di Gregorio, Giorgio Favaro, Cristina Panozzo & Mario G. Fiori

Authors
  1. Franco Di Gregorio
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  2. Giorgio Favaro
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  3. Cristina Panozzo
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  4. Mario G. Fiori
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Di Gregorio, F., Favaro, G., Panozzo, C. et al. Efficacy of ganglioside treatment in reducing functional alterations induced by vincristine in rabbit peripheral nerves. Cancer Chemother Pharmacol 26, 31 (1990). https://doi.org/10.1007/BF02940290

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  • DOI: https://doi.org/10.1007/BF02940290

Keywords

  • Sciatic Nerve
  • Conduction Velocity
  • Compound Action Potential
  • Vincristine Sulfate
  • Compound Action Potential Amplitude