Skip to main content
Log in

Examination of the mechanisms whereby heparin impairs aldosterone biosynthesis

  • Published:
Irish Journal of Medical Science Aims and scope Submit manuscript

Summary

IN the present study we have measured the plasma levels of aldosterone and its precursors in 20 patients before and during treatment with heparin which had been administered in response to usual clinical indications. Aldosterone levels fell significantly with the introduction of heparin but significant changes did not occur in the plasma levels of pregnenolone, progesterone, H-deoxycorticoster-one or corticosterone. The findings are strongly against a heparin-induced inhibition of enzyme activity along the aldosterone biosynthetic pathway. In view of this finding it is likely that heparin has a toxic effect on glomerulosa cells unrelated to a specific action on enzyme activity. Since aldosterone levels rise rapidly after withdrawal of heparin the anti-adrenal effect of the drug is promptly reversible

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Abbott, C. E., Monkhouse, F. C, Steiner, J. W., Laidlaw, J. C. 1966. Effect of a sulphated mucopolysaccharide (RO1-8307) on zona glomerulosa of the rat adrenal gland. Endocrinol. 78, 651.

    CAS  Google Scholar 

  • Abraham, G. E. 1973. Radioimmunoassay of plasma steroid hormones. In: Modern Methods of Steroid Analysis. Ed. Heftmann. Academic Press, New York and London, p. 451.

    Google Scholar 

  • Bailey, R. E., Ford, H. C. 1969. The effect of heparin on sodium conservation and on the plasma concentration, the metabolic clearance and excretion rates of aldosterone in normal subjects. Acta Endocrinol. 60, 249.

    PubMed  CAS  Google Scholar 

  • Conn, J. W., Rovner, O. E., Cohen, E. L., Anderson, J. E. 1966. Inhibition by heparinoid of aldosterone biosynthesis in man. J. Clin. Endocrinol. Metab. 26, 527.

    PubMed  CAS  Google Scholar 

  • Knochel, J. P. 1979. The syndrome of hyporeninemic hypoaldosteronism. Ann. Rev. Med. 30 145.

    Article  PubMed  CAS  Google Scholar 

  • Leehey, D., Gartt, C. Urn, V. 1981. Heparin-induced hypoaldosteronism: Report of a case JAMA 246, 2189.

    Article  PubMed  CAS  Google Scholar 

  • McDougall, J. G., Butkus, A., Coghlan, J. P., Denton, D. A., Muller, J., Oddie, C, Robinson, P. M., Scoggins, B. A. 1980. Biosynthesis and morphological evidence for inhibition of aldosterone production following administration of ACTH to sheep. Acta Endocrinol. 94, 559.

    PubMed  CAS  Google Scholar 

  • McKenna, T. J. 1981. Aldosterone secretion under physiological and pathological conditions. In: Hormones in Normal and Abnormal Human Tissues, Vol 2. Eds. K. Fotherby, S. B. Pal. Walter de Gruyer, Berlin, p. 339.

    Google Scholar 

  • McKenna, T. J., Jennings, A. S., Liddle, G. W., Burr, I. M. 1976. Pregnenolone, 17-OH-progeneolone and testosterone in patients with congenital adrenal hyperplasia. J. Clin. Endocrinol. Metab. 42, 918.

    PubMed  CAS  Google Scholar 

  • Neville, A. M., O’Hare, M. J. 1979. Aspects of structure, function and pathology. In: Comprehensive Endocrinology: The Adrenal Gland. Ed. V. H. T. James. Raven Press, New York, p. 1.

    Google Scholar 

  • O’Kelly, R., Magee, F., McKenna. 1982. Routine heparin therapy inhibits adrenal aldosterone production. J. Clin. Endocrinol. Metab. (in press).

  • Phelps, K. R., Oh, M. S., Carroll, H. J. 1980. Heparin-induced hyperkalaemia: report of a case. Nephron 25, 254.

    PubMed  CAS  Google Scholar 

  • Rabin, D., McKenna, T. J. 1982. Endocrinology and Metabolism: Principles and Practice. Grune and Stratton, New York, p. 466.

    Google Scholar 

  • Root, A. W., Bongiovanni, A, M., Eberlein, W. R. 1971. The adrenogenital syndrome. In: The Human Adrenal Cortex. Ed. N. P. Christy. Harper and Row, New York. p. 427.

    Google Scholar 

  • Rosier, A., Levine, L. S., Schneider, B., Novogroder, M., New, M. I. 1977. The interrelationship of sodium balance, plasma renin activity and ACTH in congenital adrenal hyperplasia. J. Clin. Endocrinol. Metab. 45, 500.

    Article  Google Scholar 

  • Schambelan, M., Sebastian, A. 1980. Hyporeninemic hypoaldosteronism. Adv. Intern. Med. 24, 385.

    Google Scholar 

  • Schlatmann, R. J. A. F. M., Prenan, H., Jansen, A. P., Majoor, C. I. H. 1960. The natiuretic action of heparin and some related substances. Lancet i, 34.

    Google Scholar 

  • Ulick, S. 1976. Diagnosis and nomeclature of the disorders of the terminal portion of the aldosterone biosynthetic pathway. J. Clin. Endocrinol. Metab 43, 92.

    PubMed  CAS  Google Scholar 

  • Vazir, H., Whitehouse, B. J., Vinson, G. P., McGredie, E. 1981. Effects of prolonged ACTH treatment on adrenal steroidogenesis and blood pressure in rats. Acta Endocrinol. 97, 533.

    PubMed  CAS  Google Scholar 

  • Veldhuis, J. G., Kulin, H. E., Santen, R. J., Wilson, T. E., Melby, J. C. 1980. Inborn error in the terminal step of aldosterone biosynthesis: corticosterone methyl oxidase type II deficiency in North American Pedigree. New Engl. J. Med. 303, 117.

    PubMed  CAS  Google Scholar 

  • Weidmann, P., Reinhart, R., Maxwell, M. H., Rowe, P., Coburn, J. W., Massry, S. G. 1973. Syndrome of hyporeninemic hypoaldosteronism and hyperkalemia in renal disease. J. Clin. Endocrinol. Metab. 36, 965.

    PubMed  CAS  Google Scholar 

  • Wilson, I. D., Goetz, F. C. 1964. Selective hypoaldosteronism after prolonged heparin administration. Am. J. Med. 36, 635.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kelly, R.O., McKenna, T.J. Examination of the mechanisms whereby heparin impairs aldosterone biosynthesis. Ir J Med Sci 151, 378–383 (1982). https://doi.org/10.1007/BF02940228

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02940228

Keywords

Navigation